{ "@context": { "@vocab": "https://schema.org/", "biolink": "https://w3id.org/biolink/", "orion": "https://github.com/RobokopU24/ORION" }, "@id": "https://kgx-storage.rtx.ai/releases/ctd/2026_05_26/", "@type": "Dataset", "name": "ctd", "description": "A knowledge graph built for the NCATS Biomedical Data Translator project using Translator-Ingests, Biolink Model, and Node Normalizer.", "license": "MIT", "url": "https://kgx-storage.rtx.ai/releases/ctd/2026_05_26/", "version": "ctd_April_2026_1adbe97e_2025sep1_2.4.1_1.4.0_conflated_strict_2.0.0_4.3.7", "dateCreated": "2026_05_06", "dateModified": "", "keywords": [], "creator": [], "contactPoint": [], "funder": [], "conformsTo": [], "schema": { "nodes": [ { "category": [ "biolink:SmallMolecule" ], "count": 9516, "id_prefixes": { "CHEBI": 6021, "PUBCHEM.COMPOUND": 1882, "UNII": 1613 }, "attributes": { "name": 9516, "equivalent_identifiers": 9516, "information_content": 6021, "description": 3364 } }, { "category": [ "biolink:Drug", "biolink:SmallMolecule" ], "count": 1605, "id_prefixes": { "CHEBI": 1546, "UNII": 48, "PUBCHEM.COMPOUND": 11 }, "attributes": { "name": 1605, "equivalent_identifiers": 1605, "information_content": 1534, "description": 1185 } }, { "category": [ "biolink:MolecularMixture" ], "count": 697, "id_prefixes": { "PUBCHEM.COMPOUND": 297, "CHEBI": 203, "UNII": 197 }, "attributes": { "name": 697, "equivalent_identifiers": 697, "information_content": 203, "description": 133 } }, { "category": [ "biolink:Drug" ], "count": 185, "id_prefixes": { "CHEBI": 109, "UNII": 46, "MESH": 10, "DRUGBANK": 9, "PUBCHEM.COMPOUND": 8, "CHEMBL.COMPOUND": 2, "UMLS": 1 }, "attributes": { "name": 185, "equivalent_identifiers": 185, "information_content": 114, "description": 83 } }, { "category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "count": 59, "id_prefixes": { "CHEBI": 52, "UNII": 5, "PUBCHEM.COMPOUND": 2 }, "attributes": { "name": 59, "equivalent_identifiers": 59, "information_content": 50, "description": 35 } }, { "category": [ "biolink:ChemicalEntity" ], "count": 4171, "id_prefixes": { "MESH": 3476, "CHEBI": 525, "UNII": 150, "DRUGBANK": 20 }, "attributes": { "name": 4171, "equivalent_identifiers": 4171, "information_content": 525, "description": 420 } }, { "category": [ "biolink:ChemicalMixture" ], "count": 3, "id_prefixes": { "CHEBI": 3 }, "attributes": { "name": 3, "equivalent_identifiers": 3, "information_content": 3, "description": 3 } }, { "category": [ "biolink:Disease" ], "count": 2844, "id_prefixes": { "MONDO": 2387, "UMLS": 375, "EFO": 51, "DOID": 15, "MESH": 11, "OMIM": 5 }, "attributes": { "name": 2844, "equivalent_identifiers": 2844, "information_content": 2514, "description": 2467 } }, { "category": [ "biolink:PhenotypicFeature" ], "count": 397, "id_prefixes": { "HP": 319, "NCIT": 35, "UMLS": 20, "EFO": 14, "MESH": 9 }, "attributes": { "name": 397, "equivalent_identifiers": 397, "information_content": 365, "description": 361 } }, { "category": [ "biolink:BiologicalProcess" ], "count": 7372, "id_prefixes": { "GO": 7372 }, "attributes": { "name": 7372, "equivalent_identifiers": 7372, "information_content": 7372, "description": 7372 } }, { "category": [ "biolink:MolecularActivity" ], "count": 1016, "id_prefixes": { "GO": 1016 }, "attributes": { "name": 1016, "equivalent_identifiers": 1016, "information_content": 1016, "description": 1016 } }, { "category": [ "biolink:Pathway" ], "count": 1180, "id_prefixes": { "REACT": 951, "GO": 229 }, "attributes": { "name": 1180, "equivalent_identifiers": 1180, "information_content": 229, "description": 229 } }, { "category": [ "biolink:CellularComponent" ], "count": 535, "id_prefixes": { "GO": 535 }, "attributes": { "name": 535, "equivalent_identifiers": 535, "information_content": 535, "description": 535 } }, { "category": [ "biolink:ComplexMolecularMixture" ], "count": 72, "id_prefixes": { "MESH": 72 }, "attributes": { "name": 72, "equivalent_identifiers": 72 } }, { "category": [ "biolink:Gene", "biolink:Protein" ], "count": 43746, "id_prefixes": { "NCBIGene": 43746 }, "attributes": { "name": 43746, "equivalent_identifiers": 43746, "description": 43746, "information_content": 24973 } }, { "category": [ "biolink:Gene" ], "count": 12439, "id_prefixes": { "NCBIGene": 12439 }, "attributes": { "name": 12439, "equivalent_identifiers": 12439, "description": 12412, "information_content": 999 } }, { "category": [ "biolink:Protein" ], "count": 687, "id_prefixes": { "UMLS": 687 }, "attributes": { "name": 687, "equivalent_identifiers": 687 } } ], "nodes_summary": { "total_count": 86524, "id_prefixes": { "NCBIGene": 56185, "GO": 9152, "CHEBI": 8459, "MESH": 3578, "MONDO": 2387, "PUBCHEM.COMPOUND": 2200, "UNII": 2059, "UMLS": 1083, "REACT": 951, "HP": 319, "EFO": 65, "NCIT": 35, "DRUGBANK": 29, "DOID": 15, "OMIM": 5, "CHEMBL.COMPOUND": 2 }, "attributes": { "name": 86524, "equivalent_identifiers": 86524, "description": 73361, "information_content": 46453 } }, "edges": [ { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:BiologicalProcess" ], "count": 403976, "primary_knowledge_sources": { "infores:ctd": 403976 }, "qualifiers": {}, "attributes": { "id": 403976, "category": 403976, "knowledge_level": 403976, "agent_type": 403976, "p_value": 403976, "adjusted_p_value": 403976, "original_subject": 403976, "original_object": 403976 }, "subject_id_prefixes": { "CHEBI": 370549, "PUBCHEM.COMPOUND": 17977, "UNII": 15450 }, "object_id_prefixes": { "GO": 403976 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 125885, "primary_knowledge_sources": { "infores:ctd": 125885 }, "qualifiers": { "qualified_predicate": 125885, "species_context_qualifier": 125885, "object_aspect_qualifier": 122442, "object_direction_qualifier": 100308 }, "attributes": { "id": 125885, "category": 125885, "publications": 125885, "knowledge_level": 125885, "agent_type": 125885, "original_subject": 125885, "original_object": 125885 }, "subject_id_prefixes": { "MESH": 87758, "CHEBI": 27271, "DRUGBANK": 5788, "UNII": 5068 }, "object_id_prefixes": { "NCBIGene": 125885 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 971635, "primary_knowledge_sources": { "infores:ctd": 971635 }, "qualifiers": { "qualified_predicate": 971635, "species_context_qualifier": 971635, "object_aspect_qualifier": 959470, "object_direction_qualifier": 843021 }, "attributes": { "id": 971635, "category": 971635, "publications": 971635, "knowledge_level": 971635, "agent_type": 971635, "original_subject": 971635, "original_object": 971635 }, "subject_id_prefixes": { "CHEBI": 904520, "UNII": 33606, "PUBCHEM.COMPOUND": 33509 }, "object_id_prefixes": { "NCBIGene": 971635 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:BiologicalProcess" ], "count": 20950, "primary_knowledge_sources": { "infores:ctd": 20950 }, "qualifiers": {}, "attributes": { "id": 20950, "category": 20950, "knowledge_level": 20950, "agent_type": 20950, "p_value": 20950, "adjusted_p_value": 20950, "original_subject": 20950, "original_object": 20950 }, "subject_id_prefixes": { "CHEBI": 17645, "MESH": 1103, "DRUGBANK": 872, "PUBCHEM.COMPOUND": 721, "UNII": 607, "CHEMBL.COMPOUND": 2 }, "object_id_prefixes": { "GO": 20950 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 409927, "primary_knowledge_sources": { "infores:ctd": 409927 }, "qualifiers": { "qualified_predicate": 409927, "species_context_qualifier": 409927, "object_aspect_qualifier": 400066, "object_direction_qualifier": 346272 }, "attributes": { "id": 409927, "category": 409927, "publications": 409927, "knowledge_level": 409927, "agent_type": 409927, "original_subject": 409927, "original_object": 409927 }, "subject_id_prefixes": { "CHEBI": 401160, "PUBCHEM.COMPOUND": 8036, "UNII": 731 }, "object_id_prefixes": { "NCBIGene": 409927 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:Pathway" ], "count": 196391, "primary_knowledge_sources": { "infores:ctd": 196391 }, "qualifiers": {}, "attributes": { "id": 196391, "category": 196391, "knowledge_level": 196391, "agent_type": 196391, "p_value": 196391, "adjusted_p_value": 196391, "original_subject": 196391, "original_object": 196391 }, "subject_id_prefixes": { "MESH": 113894, "CHEBI": 81334, "UNII": 867, "DRUGBANK": 296 }, "object_id_prefixes": { "REACT": 160638, "GO": 35753 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:BiologicalProcess" ], "count": 782085, "primary_knowledge_sources": { "infores:ctd": 782085 }, "qualifiers": {}, "attributes": { "id": 782085, "category": 782085, "knowledge_level": 782085, "agent_type": 782085, "p_value": 782085, "adjusted_p_value": 782085, "original_subject": 782085, "original_object": 782085 }, "subject_id_prefixes": { "MESH": 457207, "CHEBI": 318804, "UNII": 4623, "DRUGBANK": 1451 }, "object_id_prefixes": { "GO": 782085 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:CellularComponent" ], "count": 45749, "primary_knowledge_sources": { "infores:ctd": 45749 }, "qualifiers": {}, "attributes": { "id": 45749, "category": 45749, "knowledge_level": 45749, "agent_type": 45749, "p_value": 45749, "adjusted_p_value": 45749, "original_subject": 45749, "original_object": 45749 }, "subject_id_prefixes": { "CHEBI": 41897, "PUBCHEM.COMPOUND": 1940, "UNII": 1912 }, "object_id_prefixes": { "GO": 45749 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:CellularComponent" ], "count": 19424, "primary_knowledge_sources": { "infores:ctd": 19424 }, "qualifiers": {}, "attributes": { "id": 19424, "category": 19424, "knowledge_level": 19424, "agent_type": 19424, "p_value": 19424, "adjusted_p_value": 19424, "original_subject": 19424, "original_object": 19424 }, "subject_id_prefixes": { "CHEBI": 19179, "PUBCHEM.COMPOUND": 202, "UNII": 43 }, "object_id_prefixes": { "GO": 19424 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:BiologicalProcess" ], "count": 183486, "primary_knowledge_sources": { "infores:ctd": 183486 }, "qualifiers": {}, "attributes": { "id": 183486, "category": 183486, "knowledge_level": 183486, "agent_type": 183486, "p_value": 183486, "adjusted_p_value": 183486, "original_subject": 183486, "original_object": 183486 }, "subject_id_prefixes": { "CHEBI": 181322, "PUBCHEM.COMPOUND": 1605, "UNII": 559 }, "object_id_prefixes": { "GO": 183486 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:MolecularActivity" ], "count": 20477, "primary_knowledge_sources": { "infores:ctd": 20477 }, "qualifiers": {}, "attributes": { "id": 20477, "category": 20477, "knowledge_level": 20477, "agent_type": 20477, "p_value": 20477, "adjusted_p_value": 20477, "original_subject": 20477, "original_object": 20477 }, "subject_id_prefixes": { "CHEBI": 20211, "PUBCHEM.COMPOUND": 204, "UNII": 62 }, "object_id_prefixes": { "GO": 20477 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:correlated_with", "object_category": [ "biolink:Disease" ], "count": 26441, "primary_knowledge_sources": { "infores:ctd": 26441 }, "qualifiers": {}, "attributes": { "id": 26441, "category": 26441, "publications": 26441, "knowledge_level": 26441, "agent_type": 26441, "original_subject": 26441, "original_object": 26441 }, "subject_id_prefixes": { "CHEBI": 26219, "PUBCHEM.COMPOUND": 171, "UNII": 51 }, "object_id_prefixes": { "MONDO": 23297, "UMLS": 2195, "EFO": 708, "MESH": 215, "DOID": 25, "OMIM": 1 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:correlated_with", "object_category": [ "biolink:PhenotypicFeature" ], "count": 9191, "primary_knowledge_sources": { "infores:ctd": 9191 }, "qualifiers": {}, "attributes": { "id": 9191, "category": 9191, "publications": 9191, "knowledge_level": 9191, "agent_type": 9191, "original_subject": 9191, "original_object": 9191 }, "subject_id_prefixes": { "CHEBI": 9129, "PUBCHEM.COMPOUND": 52, "UNII": 10 }, "object_id_prefixes": { "HP": 8577, "NCIT": 341, "EFO": 195, "MESH": 43, "UMLS": 35 } }, { "subject_category": [ "biolink:Protein" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:BiologicalProcess" ], "count": 48902, "primary_knowledge_sources": { "infores:ctd": 48902 }, "qualifiers": {}, "attributes": { "id": 48902, "category": 48902, "knowledge_level": 48902, "agent_type": 48902, "p_value": 48902, "adjusted_p_value": 48902, "original_subject": 48902, "original_object": 48902 }, "subject_id_prefixes": { "UMLS": 48902 }, "object_id_prefixes": { "GO": 48902 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:affects", "object_category": [ "biolink:BiologicalProcess" ], "count": 9730, "primary_knowledge_sources": { "infores:ctd": 9730 }, "qualifiers": { "species_context_qualifier": 9730, "anatomical_context_qualifier": 9730, "qualified_predicate": 7577, "object_direction_qualifier": 7577 }, "attributes": { "id": 9730, "category": 9730, "publications": 9730, "knowledge_level": 9730, "agent_type": 9730, "original_subject": 9730, "original_object": 9730 }, "subject_id_prefixes": { "MESH": 7082, "CHEBI": 1864, "UNII": 713, "DRUGBANK": 71 }, "object_id_prefixes": { "GO": 9730 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:Pathway" ], "count": 40808, "primary_knowledge_sources": { "infores:ctd": 40808 }, "qualifiers": {}, "attributes": { "id": 40808, "category": 40808, "knowledge_level": 40808, "agent_type": 40808, "p_value": 40808, "adjusted_p_value": 40808, "original_subject": 40808, "original_object": 40808 }, "subject_id_prefixes": { "CHEBI": 40272, "PUBCHEM.COMPOUND": 436, "UNII": 100 }, "object_id_prefixes": { "REACT": 32222, "GO": 8586 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:BiologicalProcess" ], "count": 1134, "primary_knowledge_sources": { "infores:ctd": 1134 }, "qualifiers": {}, "attributes": { "id": 1134, "category": 1134, "publications": 1134, "knowledge_level": 1134, "agent_type": 1134, "original_subject": 1134, "original_object": 1134 }, "subject_id_prefixes": { "CHEBI": 1072, "PUBCHEM.COMPOUND": 40, "UNII": 22 }, "object_id_prefixes": { "GO": 1134 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:MolecularActivity" ], "count": 100948, "primary_knowledge_sources": { "infores:ctd": 100948 }, "qualifiers": {}, "attributes": { "id": 100948, "category": 100948, "knowledge_level": 100948, "agent_type": 100948, "p_value": 100948, "adjusted_p_value": 100948, "original_subject": 100948, "original_object": 100948 }, "subject_id_prefixes": { "MESH": 58640, "CHEBI": 41742, "UNII": 408, "DRUGBANK": 158 }, "object_id_prefixes": { "GO": 100948 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:Pathway" ], "count": 5176, "primary_knowledge_sources": { "infores:ctd": 5176 }, "qualifiers": {}, "attributes": { "id": 5176, "category": 5176, "knowledge_level": 5176, "agent_type": 5176, "p_value": 5176, "adjusted_p_value": 5176, "original_subject": 5176, "original_object": 5176 }, "subject_id_prefixes": { "CHEBI": 4601, "MESH": 177, "UNII": 158, "DRUGBANK": 135, "PUBCHEM.COMPOUND": 105 }, "object_id_prefixes": { "REACT": 4212, "GO": 964 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:BiologicalProcess" ], "count": 32565, "primary_knowledge_sources": { "infores:ctd": 32565 }, "qualifiers": { "species_context_qualifier": 32565, "anatomical_context_qualifier": 32565, "qualified_predicate": 26043, "object_direction_qualifier": 26043 }, "attributes": { "id": 32565, "category": 32565, "publications": 32565, "knowledge_level": 32565, "agent_type": 32565, "original_subject": 32565, "original_object": 32565 }, "subject_id_prefixes": { "CHEBI": 32306, "PUBCHEM.COMPOUND": 169, "UNII": 90 }, "object_id_prefixes": { "GO": 32565 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:MolecularActivity" ], "count": 3821, "primary_knowledge_sources": { "infores:ctd": 3821 }, "qualifiers": { "species_context_qualifier": 3821, "anatomical_context_qualifier": 3821, "qualified_predicate": 3629, "object_direction_qualifier": 3629 }, "attributes": { "id": 3821, "category": 3821, "publications": 3821, "knowledge_level": 3821, "agent_type": 3821, "original_subject": 3821, "original_object": 3821 }, "subject_id_prefixes": { "CHEBI": 3511, "UNII": 175, "PUBCHEM.COMPOUND": 135 }, "object_id_prefixes": { "GO": 3821 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:CellularComponent" ], "count": 89023, "primary_knowledge_sources": { "infores:ctd": 89023 }, "qualifiers": {}, "attributes": { "id": 89023, "category": 89023, "knowledge_level": 89023, "agent_type": 89023, "p_value": 89023, "adjusted_p_value": 89023, "original_subject": 89023, "original_object": 89023 }, "subject_id_prefixes": { "MESH": 52257, "CHEBI": 36199, "UNII": 355, "DRUGBANK": 212 }, "object_id_prefixes": { "GO": 89023 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:CellularComponent" ], "count": 2483, "primary_knowledge_sources": { "infores:ctd": 2483 }, "qualifiers": {}, "attributes": { "id": 2483, "category": 2483, "knowledge_level": 2483, "agent_type": 2483, "p_value": 2483, "adjusted_p_value": 2483, "original_subject": 2483, "original_object": 2483 }, "subject_id_prefixes": { "CHEBI": 2236, "UNII": 73, "DRUGBANK": 72, "MESH": 72, "PUBCHEM.COMPOUND": 30 }, "object_id_prefixes": { "GO": 2483 } }, { "subject_category": [ "biolink:ComplexMolecularMixture" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 45004, "primary_knowledge_sources": { "infores:ctd": 45004 }, "qualifiers": { "qualified_predicate": 45004, "species_context_qualifier": 45004, "object_aspect_qualifier": 44819, "object_direction_qualifier": 38646 }, "attributes": { "id": 45004, "category": 45004, "publications": 45004, "knowledge_level": 45004, "agent_type": 45004, "original_subject": 45004, "original_object": 45004 }, "subject_id_prefixes": { "MESH": 45004 }, "object_id_prefixes": { "NCBIGene": 45004 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene" ], "count": 2115, "primary_knowledge_sources": { "infores:ctd": 2115 }, "qualifiers": { "qualified_predicate": 2115, "species_context_qualifier": 2115, "object_aspect_qualifier": 2058, "object_direction_qualifier": 1819 }, "attributes": { "id": 2115, "category": 2115, "publications": 2115, "knowledge_level": 2115, "agent_type": 2115, "original_subject": 2115, "original_object": 2115 }, "subject_id_prefixes": { "CHEBI": 2077, "UNII": 15, "DRUGBANK": 11, "MESH": 7, "PUBCHEM.COMPOUND": 5 }, "object_id_prefixes": { "NCBIGene": 2115 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object_category": [ "biolink:Disease" ], "count": 16787, "primary_knowledge_sources": { "infores:ctd": 16787 }, "qualifiers": {}, "attributes": { "id": 16787, "category": 16787, "publications": 16787, "knowledge_level": 16787, "agent_type": 16787, "original_subject": 16787, "original_object": 16787 }, "subject_id_prefixes": { "CHEBI": 16558, "PUBCHEM.COMPOUND": 153, "UNII": 76 }, "object_id_prefixes": { "MONDO": 14736, "UMLS": 1438, "EFO": 460, "MESH": 130, "DOID": 20, "OMIM": 3 } }, { "subject_category": [ "biolink:Protein" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:MolecularActivity" ], "count": 5263, "primary_knowledge_sources": { "infores:ctd": 5263 }, "qualifiers": {}, "attributes": { "id": 5263, "category": 5263, "knowledge_level": 5263, "agent_type": 5263, "p_value": 5263, "adjusted_p_value": 5263, "original_subject": 5263, "original_object": 5263 }, "subject_id_prefixes": { "UMLS": 5263 }, "object_id_prefixes": { "GO": 5263 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 45898, "primary_knowledge_sources": { "infores:ctd": 45898 }, "qualifiers": { "qualified_predicate": 45898, "species_context_qualifier": 45898, "object_aspect_qualifier": 44812, "object_direction_qualifier": 38952 }, "attributes": { "id": 45898, "category": 45898, "publications": 45898, "knowledge_level": 45898, "agent_type": 45898, "original_subject": 45898, "original_object": 45898 }, "subject_id_prefixes": { "CHEBI": 43848, "UNII": 961, "DRUGBANK": 544, "PUBCHEM.COMPOUND": 313, "MESH": 220, "CHEMBL.COMPOUND": 9, "UMLS": 3 }, "object_id_prefixes": { "NCBIGene": 45898 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:MolecularActivity" ], "count": 48502, "primary_knowledge_sources": { "infores:ctd": 48502 }, "qualifiers": {}, "attributes": { "id": 48502, "category": 48502, "knowledge_level": 48502, "agent_type": 48502, "p_value": 48502, "adjusted_p_value": 48502, "original_subject": 48502, "original_object": 48502 }, "subject_id_prefixes": { "CHEBI": 44419, "PUBCHEM.COMPOUND": 2126, "UNII": 1957 }, "object_id_prefixes": { "GO": 48502 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 67521, "primary_knowledge_sources": { "infores:ctd": 67521 }, "qualifiers": { "qualified_predicate": 67521, "species_context_qualifier": 67521, "object_aspect_qualifier": 66790, "object_direction_qualifier": 62580 }, "attributes": { "id": 67521, "category": 67521, "publications": 67521, "knowledge_level": 67521, "agent_type": 67521, "original_subject": 67521, "original_object": 67521 }, "subject_id_prefixes": { "CHEBI": 53044, "PUBCHEM.COMPOUND": 10419, "UNII": 4058 }, "object_id_prefixes": { "NCBIGene": 67521 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene" ], "count": 31290, "primary_knowledge_sources": { "infores:ctd": 31290 }, "qualifiers": { "qualified_predicate": 31290, "species_context_qualifier": 31290, "object_aspect_qualifier": 31055, "object_direction_qualifier": 28597 }, "attributes": { "id": 31290, "category": 31290, "publications": 31290, "knowledge_level": 31290, "agent_type": 31290, "original_subject": 31290, "original_object": 31290 }, "subject_id_prefixes": { "CHEBI": 30145, "PUBCHEM.COMPOUND": 696, "UNII": 449 }, "object_id_prefixes": { "NCBIGene": 31290 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene" ], "count": 4338, "primary_knowledge_sources": { "infores:ctd": 4338 }, "qualifiers": { "qualified_predicate": 4338, "species_context_qualifier": 4338, "object_aspect_qualifier": 4315, "object_direction_qualifier": 3578 }, "attributes": { "id": 4338, "category": 4338, "publications": 4338, "knowledge_level": 4338, "agent_type": 4338, "original_subject": 4338, "original_object": 4338 }, "subject_id_prefixes": { "MESH": 3049, "CHEBI": 603, "DRUGBANK": 433, "UNII": 253 }, "object_id_prefixes": { "NCBIGene": 4338 } }, { "subject_category": [ "biolink:Protein" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:Pathway" ], "count": 10716, "primary_knowledge_sources": { "infores:ctd": 10716 }, "qualifiers": {}, "attributes": { "id": 10716, "category": 10716, "knowledge_level": 10716, "agent_type": 10716, "p_value": 10716, "adjusted_p_value": 10716, "original_subject": 10716, "original_object": 10716 }, "subject_id_prefixes": { "UMLS": 10716 }, "object_id_prefixes": { "REACT": 8375, "GO": 2341 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:Pathway" ], "count": 98928, "primary_knowledge_sources": { "infores:ctd": 98928 }, "qualifiers": {}, "attributes": { "id": 98928, "category": 98928, "knowledge_level": 98928, "agent_type": 98928, "p_value": 98928, "adjusted_p_value": 98928, "original_subject": 98928, "original_object": 98928 }, "subject_id_prefixes": { "CHEBI": 90003, "PUBCHEM.COMPOUND": 5035, "UNII": 3890 }, "object_id_prefixes": { "REACT": 79737, "GO": 19191 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object_category": [ "biolink:Disease" ], "count": 8706, "primary_knowledge_sources": { "infores:ctd": 8706 }, "qualifiers": {}, "attributes": { "id": 8706, "category": 8706, "publications": 8706, "knowledge_level": 8706, "agent_type": 8706, "original_subject": 8706, "original_object": 8706 }, "subject_id_prefixes": { "CHEBI": 6948, "UNII": 950, "PUBCHEM.COMPOUND": 808 }, "object_id_prefixes": { "MONDO": 7166, "UMLS": 960, "EFO": 441, "MESH": 135, "OMIM": 2, "DOID": 2 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:Pathway" ], "count": 5969, "primary_knowledge_sources": { "infores:ctd": 5969 }, "qualifiers": {}, "attributes": { "id": 5969, "category": 5969, "knowledge_level": 5969, "agent_type": 5969, "p_value": 5969, "adjusted_p_value": 5969, "original_subject": 5969, "original_object": 5969 }, "subject_id_prefixes": { "CHEBI": 4459, "PUBCHEM.COMPOUND": 1076, "UNII": 434 }, "object_id_prefixes": { "REACT": 4823, "GO": 1146 } }, { "subject_category": [ "biolink:Protein" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 23466, "primary_knowledge_sources": { "infores:ctd": 23466 }, "qualifiers": { "qualified_predicate": 23466, "species_context_qualifier": 23466, "object_aspect_qualifier": 23090, "object_direction_qualifier": 21667 }, "attributes": { "id": 23466, "category": 23466, "publications": 23466, "knowledge_level": 23466, "agent_type": 23466, "original_subject": 23466, "original_object": 23466 }, "subject_id_prefixes": { "UMLS": 23466 }, "object_id_prefixes": { "NCBIGene": 23466 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object_category": [ "biolink:PhenotypicFeature" ], "count": 2167, "primary_knowledge_sources": { "infores:ctd": 2167 }, "qualifiers": {}, "attributes": { "id": 2167, "category": 2167, "publications": 2167, "knowledge_level": 2167, "agent_type": 2167, "original_subject": 2167, "original_object": 2167 }, "subject_id_prefixes": { "CHEBI": 1707, "UNII": 230, "PUBCHEM.COMPOUND": 230 }, "object_id_prefixes": { "HP": 1825, "NCIT": 250, "EFO": 40, "MESH": 31, "UMLS": 21 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:correlated_with", "object_category": [ "biolink:Disease" ], "count": 15599, "primary_knowledge_sources": { "infores:ctd": 15599 }, "qualifiers": {}, "attributes": { "id": 15599, "category": 15599, "publications": 15599, "knowledge_level": 15599, "agent_type": 15599, "original_subject": 15599, "original_object": 15599 }, "subject_id_prefixes": { "CHEBI": 13885, "UNII": 1048, "PUBCHEM.COMPOUND": 666 }, "object_id_prefixes": { "MONDO": 12420, "UMLS": 2203, "EFO": 752, "MESH": 166, "DOID": 44, "OMIM": 14 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:BiologicalProcess" ], "count": 52567, "primary_knowledge_sources": { "infores:ctd": 52567 }, "qualifiers": { "species_context_qualifier": 52567, "anatomical_context_qualifier": 52567, "qualified_predicate": 39789, "object_direction_qualifier": 39789 }, "attributes": { "id": 52567, "category": 52567, "publications": 52567, "knowledge_level": 52567, "agent_type": 52567, "original_subject": 52567, "original_object": 52567 }, "subject_id_prefixes": { "CHEBI": 47279, "UNII": 2820, "PUBCHEM.COMPOUND": 2468 }, "object_id_prefixes": { "GO": 52567 } }, { "subject_category": [ "biolink:Protein" ], "predicate": "biolink:affects", "object_category": [ "biolink:BiologicalProcess" ], "count": 2416, "primary_knowledge_sources": { "infores:ctd": 2416 }, "qualifiers": { "species_context_qualifier": 2416, "anatomical_context_qualifier": 2416, "qualified_predicate": 1927, "object_direction_qualifier": 1927 }, "attributes": { "id": 2416, "category": 2416, "publications": 2416, "knowledge_level": 2416, "agent_type": 2416, "original_subject": 2416, "original_object": 2416 }, "subject_id_prefixes": { "UMLS": 2416 }, "object_id_prefixes": { "GO": 2416 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:CellularComponent" ], "count": 2789, "primary_knowledge_sources": { "infores:ctd": 2789 }, "qualifiers": {}, "attributes": { "id": 2789, "category": 2789, "knowledge_level": 2789, "agent_type": 2789, "p_value": 2789, "adjusted_p_value": 2789, "original_subject": 2789, "original_object": 2789 }, "subject_id_prefixes": { "CHEBI": 1963, "PUBCHEM.COMPOUND": 556, "UNII": 270 }, "object_id_prefixes": { "GO": 2789 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:correlated_with", "object_category": [ "biolink:PhenotypicFeature" ], "count": 1156, "primary_knowledge_sources": { "infores:ctd": 1156 }, "qualifiers": {}, "attributes": { "id": 1156, "category": 1156, "publications": 1156, "knowledge_level": 1156, "agent_type": 1156, "original_subject": 1156, "original_object": 1156 }, "subject_id_prefixes": { "MESH": 670, "CHEBI": 435, "UNII": 46, "DRUGBANK": 5 }, "object_id_prefixes": { "HP": 972, "NCIT": 98, "EFO": 45, "MESH": 32, "UMLS": 9 } }, { "subject_category": [ "biolink:ComplexMolecularMixture" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:BiologicalProcess" ], "count": 23717, "primary_knowledge_sources": { "infores:ctd": 23717 }, "qualifiers": {}, "attributes": { "id": 23717, "category": 23717, "knowledge_level": 23717, "agent_type": 23717, "p_value": 23717, "adjusted_p_value": 23717, "original_subject": 23717, "original_object": 23717 }, "subject_id_prefixes": { "MESH": 23717 }, "object_id_prefixes": { "GO": 23717 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:MolecularActivity" ], "count": 2982, "primary_knowledge_sources": { "infores:ctd": 2982 }, "qualifiers": {}, "attributes": { "id": 2982, "category": 2982, "knowledge_level": 2982, "agent_type": 2982, "p_value": 2982, "adjusted_p_value": 2982, "original_subject": 2982, "original_object": 2982 }, "subject_id_prefixes": { "CHEBI": 2280, "PUBCHEM.COMPOUND": 494, "UNII": 208 }, "object_id_prefixes": { "GO": 2982 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:BiologicalProcess" ], "count": 24358, "primary_knowledge_sources": { "infores:ctd": 24358 }, "qualifiers": {}, "attributes": { "id": 24358, "category": 24358, "knowledge_level": 24358, "agent_type": 24358, "p_value": 24358, "adjusted_p_value": 24358, "original_subject": 24358, "original_object": 24358 }, "subject_id_prefixes": { "CHEBI": 17960, "PUBCHEM.COMPOUND": 4208, "UNII": 2190 }, "object_id_prefixes": { "GO": 24358 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene" ], "count": 11971, "primary_knowledge_sources": { "infores:ctd": 11971 }, "qualifiers": { "qualified_predicate": 11971, "species_context_qualifier": 11971, "object_aspect_qualifier": 11835, "object_direction_qualifier": 11019 }, "attributes": { "id": 11971, "category": 11971, "publications": 11971, "knowledge_level": 11971, "agent_type": 11971, "original_subject": 11971, "original_object": 11971 }, "subject_id_prefixes": { "CHEBI": 11889, "PUBCHEM.COMPOUND": 74, "UNII": 8 }, "object_id_prefixes": { "NCBIGene": 11971 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 5501, "primary_knowledge_sources": { "infores:ctd": 5501 }, "qualifiers": { "qualified_predicate": 5501, "species_context_qualifier": 5501, "object_aspect_qualifier": 5429, "object_direction_qualifier": 5335 }, "attributes": { "id": 5501, "category": 5501, "publications": 5501, "knowledge_level": 5501, "agent_type": 5501, "original_subject": 5501, "original_object": 5501 }, "subject_id_prefixes": { "CHEBI": 5490, "UNII": 10, "PUBCHEM.COMPOUND": 1 }, "object_id_prefixes": { "NCBIGene": 5501 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:MolecularActivity" ], "count": 488, "primary_knowledge_sources": { "infores:ctd": 488 }, "qualifiers": {}, "attributes": { "id": 488, "category": 488, "knowledge_level": 488, "agent_type": 488, "p_value": 488, "adjusted_p_value": 488, "original_subject": 488, "original_object": 488 }, "subject_id_prefixes": { "CHEBI": 486, "UNII": 2 }, "object_id_prefixes": { "GO": 488 } }, { "subject_category": [ "biolink:Protein" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene" ], "count": 921, "primary_knowledge_sources": { "infores:ctd": 921 }, "qualifiers": { "qualified_predicate": 921, "species_context_qualifier": 921, "object_aspect_qualifier": 905, "object_direction_qualifier": 858 }, "attributes": { "id": 921, "category": 921, "publications": 921, "knowledge_level": 921, "agent_type": 921, "original_subject": 921, "original_object": 921 }, "subject_id_prefixes": { "UMLS": 921 }, "object_id_prefixes": { "NCBIGene": 921 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:affects", "object_category": [ "biolink:MolecularActivity" ], "count": 437, "primary_knowledge_sources": { "infores:ctd": 437 }, "qualifiers": { "species_context_qualifier": 437, "anatomical_context_qualifier": 437, "qualified_predicate": 418, "object_direction_qualifier": 418 }, "attributes": { "id": 437, "category": 437, "publications": 437, "knowledge_level": 437, "agent_type": 437, "original_subject": 437, "original_object": 437 }, "subject_id_prefixes": { "CHEBI": 386, "PUBCHEM.COMPOUND": 37, "UNII": 14 }, "object_id_prefixes": { "GO": 437 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:correlated_with", "object_category": [ "biolink:Disease" ], "count": 1600, "primary_knowledge_sources": { "infores:ctd": 1600 }, "qualifiers": {}, "attributes": { "id": 1600, "category": 1600, "publications": 1600, "knowledge_level": 1600, "agent_type": 1600, "original_subject": 1600, "original_object": 1600 }, "subject_id_prefixes": { "CHEBI": 1001, "PUBCHEM.COMPOUND": 442, "UNII": 157 }, "object_id_prefixes": { "MONDO": 1328, "UMLS": 194, "EFO": 64, "MESH": 11, "DOID": 2, "OMIM": 1 } }, { "subject_category": [ "biolink:Protein" ], "predicate": "biolink:correlated_with", "object_category": [ "biolink:Disease" ], "count": 1034, "primary_knowledge_sources": { "infores:ctd": 1034 }, "qualifiers": {}, "attributes": { "id": 1034, "category": 1034, "publications": 1034, "knowledge_level": 1034, "agent_type": 1034, "original_subject": 1034, "original_object": 1034 }, "subject_id_prefixes": { "UMLS": 1034 }, "object_id_prefixes": { "MONDO": 882, "UMLS": 87, "EFO": 48, "MESH": 15, "OMIM": 1, "DOID": 1 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:MolecularActivity" ], "count": 1729, "primary_knowledge_sources": { "infores:ctd": 1729 }, "qualifiers": { "species_context_qualifier": 1729, "anatomical_context_qualifier": 1729, "qualified_predicate": 1666, "object_direction_qualifier": 1666 }, "attributes": { "id": 1729, "category": 1729, "publications": 1729, "knowledge_level": 1729, "agent_type": 1729, "original_subject": 1729, "original_object": 1729 }, "subject_id_prefixes": { "CHEBI": 1700, "UNII": 19, "PUBCHEM.COMPOUND": 10 }, "object_id_prefixes": { "GO": 1729 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:BiologicalProcess" ], "count": 4601, "primary_knowledge_sources": { "infores:ctd": 4601 }, "qualifiers": {}, "attributes": { "id": 4601, "category": 4601, "knowledge_level": 4601, "agent_type": 4601, "p_value": 4601, "adjusted_p_value": 4601, "original_subject": 4601, "original_object": 4601 }, "subject_id_prefixes": { "CHEBI": 4598, "UNII": 3 }, "object_id_prefixes": { "GO": 4601 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:affects", "object_category": [ "biolink:MolecularActivity" ], "count": 301, "primary_knowledge_sources": { "infores:ctd": 301 }, "qualifiers": { "species_context_qualifier": 301, "anatomical_context_qualifier": 301, "qualified_predicate": 288, "object_direction_qualifier": 288 }, "attributes": { "id": 301, "category": 301, "publications": 301, "knowledge_level": 301, "agent_type": 301, "original_subject": 301, "original_object": 301 }, "subject_id_prefixes": { "CHEBI": 286, "PUBCHEM.COMPOUND": 9, "UNII": 3, "MESH": 3 }, "object_id_prefixes": { "GO": 301 } }, { "subject_category": [ "biolink:ComplexMolecularMixture" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:CellularComponent" ], "count": 2932, "primary_knowledge_sources": { "infores:ctd": 2932 }, "qualifiers": {}, "attributes": { "id": 2932, "category": 2932, "knowledge_level": 2932, "agent_type": 2932, "p_value": 2932, "adjusted_p_value": 2932, "original_subject": 2932, "original_object": 2932 }, "subject_id_prefixes": { "MESH": 2932 }, "object_id_prefixes": { "GO": 2932 } }, { "subject_category": [ "biolink:ComplexMolecularMixture" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:MolecularActivity" ], "count": 3222, "primary_knowledge_sources": { "infores:ctd": 3222 }, "qualifiers": {}, "attributes": { "id": 3222, "category": 3222, "knowledge_level": 3222, "agent_type": 3222, "p_value": 3222, "adjusted_p_value": 3222, "original_subject": 3222, "original_object": 3222 }, "subject_id_prefixes": { "MESH": 3222 }, "object_id_prefixes": { "GO": 3222 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:correlated_with", "object_category": [ "biolink:Disease" ], "count": 4212, "primary_knowledge_sources": { "infores:ctd": 4212 }, "qualifiers": {}, "attributes": { "id": 4212, "category": 4212, "publications": 4212, "knowledge_level": 4212, "agent_type": 4212, "original_subject": 4212, "original_object": 4212 }, "subject_id_prefixes": { "MESH": 2173, "CHEBI": 1832, "UNII": 171, "DRUGBANK": 36 }, "object_id_prefixes": { "MONDO": 3556, "UMLS": 441, "EFO": 159, "MESH": 45, "DOID": 8, "OMIM": 3 } }, { "subject_category": [ "biolink:ComplexMolecularMixture" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:Pathway" ], "count": 6285, "primary_knowledge_sources": { "infores:ctd": 6285 }, "qualifiers": {}, "attributes": { "id": 6285, "category": 6285, "knowledge_level": 6285, "agent_type": 6285, "p_value": 6285, "adjusted_p_value": 6285, "original_subject": 6285, "original_object": 6285 }, "subject_id_prefixes": { "MESH": 6285 }, "object_id_prefixes": { "REACT": 5218, "GO": 1067 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene" ], "count": 3340, "primary_knowledge_sources": { "infores:ctd": 3340 }, "qualifiers": { "qualified_predicate": 3340, "species_context_qualifier": 3340, "object_aspect_qualifier": 3323, "object_direction_qualifier": 3234 }, "attributes": { "id": 3340, "category": 3340, "publications": 3340, "knowledge_level": 3340, "agent_type": 3340, "original_subject": 3340, "original_object": 3340 }, "subject_id_prefixes": { "CHEBI": 3048, "PUBCHEM.COMPOUND": 202, "UNII": 90 }, "object_id_prefixes": { "NCBIGene": 3340 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object_category": [ "biolink:Disease" ], "count": 837, "primary_knowledge_sources": { "infores:ctd": 837 }, "qualifiers": {}, "attributes": { "id": 837, "category": 837, "publications": 837, "knowledge_level": 837, "agent_type": 837, "original_subject": 837, "original_object": 837 }, "subject_id_prefixes": { "CHEBI": 606, "UNII": 128, "PUBCHEM.COMPOUND": 56, "DRUGBANK": 31, "MESH": 14, "CHEMBL.COMPOUND": 2 }, "object_id_prefixes": { "MONDO": 742, "UMLS": 70, "EFO": 17, "MESH": 8 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:affects", "object_category": [ "biolink:BiologicalProcess" ], "count": 4871, "primary_knowledge_sources": { "infores:ctd": 4871 }, "qualifiers": { "species_context_qualifier": 4871, "anatomical_context_qualifier": 4871, "qualified_predicate": 3737, "object_direction_qualifier": 3737 }, "attributes": { "id": 4871, "category": 4871, "publications": 4871, "knowledge_level": 4871, "agent_type": 4871, "original_subject": 4871, "original_object": 4871 }, "subject_id_prefixes": { "CHEBI": 3947, "PUBCHEM.COMPOUND": 521, "UNII": 403 }, "object_id_prefixes": { "GO": 4871 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:MolecularActivity" ], "count": 2432, "primary_knowledge_sources": { "infores:ctd": 2432 }, "qualifiers": {}, "attributes": { "id": 2432, "category": 2432, "knowledge_level": 2432, "agent_type": 2432, "p_value": 2432, "adjusted_p_value": 2432, "original_subject": 2432, "original_object": 2432 }, "subject_id_prefixes": { "CHEBI": 2183, "MESH": 77, "DRUGBANK": 69, "UNII": 57, "PUBCHEM.COMPOUND": 46 }, "object_id_prefixes": { "GO": 2432 } }, { "subject_category": [ "biolink:Protein" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:CellularComponent" ], "count": 4871, "primary_knowledge_sources": { "infores:ctd": 4871 }, "qualifiers": {}, "attributes": { "id": 4871, "category": 4871, "knowledge_level": 4871, "agent_type": 4871, "p_value": 4871, "adjusted_p_value": 4871, "original_subject": 4871, "original_object": 4871 }, "subject_id_prefixes": { "UMLS": 4871 }, "object_id_prefixes": { "GO": 4871 } }, { "subject_category": [ "biolink:ChemicalMixture" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:BiologicalProcess" ], "count": 1518, "primary_knowledge_sources": { "infores:ctd": 1518 }, "qualifiers": {}, "attributes": { "id": 1518, "category": 1518, "knowledge_level": 1518, "agent_type": 1518, "p_value": 1518, "adjusted_p_value": 1518, "original_subject": 1518, "original_object": 1518 }, "subject_id_prefixes": { "CHEBI": 1518 }, "object_id_prefixes": { "GO": 1518 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:affects", "object_category": [ "biolink:BiologicalProcess" ], "count": 3202, "primary_knowledge_sources": { "infores:ctd": 3202 }, "qualifiers": { "species_context_qualifier": 3202, "anatomical_context_qualifier": 3202, "qualified_predicate": 2657, "object_direction_qualifier": 2657 }, "attributes": { "id": 3202, "category": 3202, "publications": 3202, "knowledge_level": 3202, "agent_type": 3202, "original_subject": 3202, "original_object": 3202 }, "subject_id_prefixes": { "CHEBI": 2893, "PUBCHEM.COMPOUND": 149, "UNII": 95, "DRUGBANK": 37, "MESH": 26, "CHEMBL.COMPOUND": 2 }, "object_id_prefixes": { "GO": 3202 } }, { "subject_category": [ "biolink:ComplexMolecularMixture" ], "predicate": "biolink:affects", "object_category": [ "biolink:BiologicalProcess" ], "count": 2224, "primary_knowledge_sources": { "infores:ctd": 2224 }, "qualifiers": { "species_context_qualifier": 2224, "anatomical_context_qualifier": 2224, "qualified_predicate": 1707, "object_direction_qualifier": 1707 }, "attributes": { "id": 2224, "category": 2224, "publications": 2224, "knowledge_level": 2224, "agent_type": 2224, "original_subject": 2224, "original_object": 2224 }, "subject_id_prefixes": { "MESH": 2224 }, "object_id_prefixes": { "GO": 2224 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene" ], "count": 534, "primary_knowledge_sources": { "infores:ctd": 534 }, "qualifiers": { "object_aspect_qualifier": 534, "qualified_predicate": 534, "species_context_qualifier": 534, "object_direction_qualifier": 525 }, "attributes": { "id": 534, "category": 534, "publications": 534, "knowledge_level": 534, "agent_type": 534, "original_subject": 534, "original_object": 534 }, "subject_id_prefixes": { "CHEBI": 534 }, "object_id_prefixes": { "NCBIGene": 534 } }, { "subject_category": [ "biolink:ComplexMolecularMixture" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene" ], "count": 3209, "primary_knowledge_sources": { "infores:ctd": 3209 }, "qualifiers": { "qualified_predicate": 3209, "species_context_qualifier": 3209, "object_aspect_qualifier": 3206, "object_direction_qualifier": 3025 }, "attributes": { "id": 3209, "category": 3209, "publications": 3209, "knowledge_level": 3209, "agent_type": 3209, "original_subject": 3209, "original_object": 3209 }, "subject_id_prefixes": { "MESH": 3209 }, "object_id_prefixes": { "NCBIGene": 3209 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:correlated_with", "object_category": [ "biolink:PhenotypicFeature" ], "count": 4216, "primary_knowledge_sources": { "infores:ctd": 4216 }, "qualifiers": {}, "attributes": { "id": 4216, "category": 4216, "publications": 4216, "knowledge_level": 4216, "agent_type": 4216, "original_subject": 4216, "original_object": 4216 }, "subject_id_prefixes": { "CHEBI": 3704, "UNII": 332, "PUBCHEM.COMPOUND": 180 }, "object_id_prefixes": { "HP": 3480, "NCIT": 324, "EFO": 216, "MESH": 128, "UMLS": 68 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:Disease" ], "count": 358, "primary_knowledge_sources": { "infores:ctd": 358 }, "qualifiers": {}, "attributes": { "id": 358, "category": 358, "publications": 358, "knowledge_level": 358, "agent_type": 358, "original_subject": 358, "original_object": 358 }, "subject_id_prefixes": { "CHEBI": 228, "MESH": 125, "DRUGBANK": 3, "UNII": 2 }, "object_id_prefixes": { "MONDO": 306, "UMLS": 39, "EFO": 11, "OMIM": 1, "DOID": 1 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object_category": [ "biolink:Disease" ], "count": 745, "primary_knowledge_sources": { "infores:ctd": 745 }, "qualifiers": {}, "attributes": { "id": 745, "category": 745, "publications": 745, "knowledge_level": 745, "agent_type": 745, "original_subject": 745, "original_object": 745 }, "subject_id_prefixes": { "CHEBI": 376, "PUBCHEM.COMPOUND": 228, "UNII": 141 }, "object_id_prefixes": { "MONDO": 636, "UMLS": 69, "EFO": 29, "MESH": 9, "DOID": 2 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:Pathway" ], "count": 441, "primary_knowledge_sources": { "infores:ctd": 441 }, "qualifiers": { "species_context_qualifier": 441, "anatomical_context_qualifier": 441, "qualified_predicate": 341, "object_direction_qualifier": 341 }, "attributes": { "id": 441, "category": 441, "publications": 441, "knowledge_level": 441, "agent_type": 441, "original_subject": 441, "original_object": 441 }, "subject_id_prefixes": { "CHEBI": 407, "PUBCHEM.COMPOUND": 17, "UNII": 17 }, "object_id_prefixes": { "GO": 441 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object_category": [ "biolink:Disease" ], "count": 3166, "primary_knowledge_sources": { "infores:ctd": 3166 }, "qualifiers": {}, "attributes": { "id": 3166, "category": 3166, "publications": 3166, "knowledge_level": 3166, "agent_type": 3166, "original_subject": 3166, "original_object": 3166 }, "subject_id_prefixes": { "MESH": 2232, "CHEBI": 705, "UNII": 194, "DRUGBANK": 35 }, "object_id_prefixes": { "MONDO": 2637, "UMLS": 331, "EFO": 137, "MESH": 60, "DOID": 1 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:correlated_with", "object_category": [ "biolink:Disease" ], "count": 1431, "primary_knowledge_sources": { "infores:ctd": 1431 }, "qualifiers": {}, "attributes": { "id": 1431, "category": 1431, "publications": 1431, "knowledge_level": 1431, "agent_type": 1431, "original_subject": 1431, "original_object": 1431 }, "subject_id_prefixes": { "CHEBI": 1046, "UNII": 272, "PUBCHEM.COMPOUND": 55, "DRUGBANK": 37, "MESH": 18, "CHEMBL.COMPOUND": 3 }, "object_id_prefixes": { "MONDO": 1229, "UMLS": 135, "EFO": 47, "MESH": 18, "DOID": 2 } }, { "subject_category": [ "biolink:ChemicalMixture" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:Pathway" ], "count": 449, "primary_knowledge_sources": { "infores:ctd": 449 }, "qualifiers": {}, "attributes": { "id": 449, "category": 449, "knowledge_level": 449, "agent_type": 449, "p_value": 449, "adjusted_p_value": 449, "original_subject": 449, "original_object": 449 }, "subject_id_prefixes": { "CHEBI": 449 }, "object_id_prefixes": { "REACT": 379, "GO": 70 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:Disease" ], "count": 1114, "primary_knowledge_sources": { "infores:ctd": 1114 }, "qualifiers": {}, "attributes": { "id": 1114, "category": 1114, "publications": 1114, "knowledge_level": 1114, "agent_type": 1114, "original_subject": 1114, "original_object": 1114 }, "subject_id_prefixes": { "CHEBI": 1081, "UNII": 24, "PUBCHEM.COMPOUND": 9 }, "object_id_prefixes": { "MONDO": 941, "UMLS": 156, "OMIM": 8, "DOID": 5, "EFO": 3, "MESH": 1 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object_category": [ "biolink:PhenotypicFeature" ], "count": 3582, "primary_knowledge_sources": { "infores:ctd": 3582 }, "qualifiers": {}, "attributes": { "id": 3582, "category": 3582, "publications": 3582, "knowledge_level": 3582, "agent_type": 3582, "original_subject": 3582, "original_object": 3582 }, "subject_id_prefixes": { "CHEBI": 3554, "PUBCHEM.COMPOUND": 16, "UNII": 12 }, "object_id_prefixes": { "HP": 3048, "NCIT": 342, "EFO": 93, "MESH": 57, "UMLS": 42 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:CellularComponent" ], "count": 406, "primary_knowledge_sources": { "infores:ctd": 406 }, "qualifiers": {}, "attributes": { "id": 406, "category": 406, "knowledge_level": 406, "agent_type": 406, "p_value": 406, "adjusted_p_value": 406, "original_subject": 406, "original_object": 406 }, "subject_id_prefixes": { "CHEBI": 406 }, "object_id_prefixes": { "GO": 406 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:correlated_with", "object_category": [ "biolink:PhenotypicFeature" ], "count": 532, "primary_knowledge_sources": { "infores:ctd": 532 }, "qualifiers": {}, "attributes": { "id": 532, "category": 532, "publications": 532, "knowledge_level": 532, "agent_type": 532, "original_subject": 532, "original_object": 532 }, "subject_id_prefixes": { "CHEBI": 322, "PUBCHEM.COMPOUND": 171, "UNII": 39 }, "object_id_prefixes": { "HP": 470, "NCIT": 34, "EFO": 13, "MESH": 12, "UMLS": 3 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object_category": [ "biolink:PhenotypicFeature" ], "count": 795, "primary_knowledge_sources": { "infores:ctd": 795 }, "qualifiers": {}, "attributes": { "id": 795, "category": 795, "publications": 795, "knowledge_level": 795, "agent_type": 795, "original_subject": 795, "original_object": 795 }, "subject_id_prefixes": { "MESH": 577, "CHEBI": 157, "UNII": 56, "DRUGBANK": 5 }, "object_id_prefixes": { "HP": 657, "NCIT": 108, "MESH": 13, "EFO": 9, "UMLS": 8 } }, { "subject_category": [ "biolink:ChemicalMixture" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:CellularComponent" ], "count": 176, "primary_knowledge_sources": { "infores:ctd": 176 }, "qualifiers": {}, "attributes": { "id": 176, "category": 176, "knowledge_level": 176, "agent_type": 176, "p_value": 176, "adjusted_p_value": 176, "original_subject": 176, "original_object": 176 }, "subject_id_prefixes": { "CHEBI": 176 }, "object_id_prefixes": { "GO": 176 } }, { "subject_category": [ "biolink:Protein" ], "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object_category": [ "biolink:Disease" ], "count": 848, "primary_knowledge_sources": { "infores:ctd": 848 }, "qualifiers": {}, "attributes": { "id": 848, "category": 848, "publications": 848, "knowledge_level": 848, "agent_type": 848, "original_subject": 848, "original_object": 848 }, "subject_id_prefixes": { "UMLS": 848 }, "object_id_prefixes": { "MONDO": 707, "UMLS": 92, "EFO": 33, "MESH": 16 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:affects", "object_category": [ "biolink:MolecularActivity" ], "count": 518, "primary_knowledge_sources": { "infores:ctd": 518 }, "qualifiers": { "species_context_qualifier": 518, "anatomical_context_qualifier": 518, "qualified_predicate": 499, "object_direction_qualifier": 499 }, "attributes": { "id": 518, "category": 518, "publications": 518, "knowledge_level": 518, "agent_type": 518, "original_subject": 518, "original_object": 518 }, "subject_id_prefixes": { "MESH": 307, "CHEBI": 149, "UNII": 61, "DRUGBANK": 1 }, "object_id_prefixes": { "GO": 518 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:correlated_with", "object_category": [ "biolink:PhenotypicFeature" ], "count": 477, "primary_knowledge_sources": { "infores:ctd": 477 }, "qualifiers": {}, "attributes": { "id": 477, "category": 477, "publications": 477, "knowledge_level": 477, "agent_type": 477, "original_subject": 477, "original_object": 477 }, "subject_id_prefixes": { "CHEBI": 352, "UNII": 81, "PUBCHEM.COMPOUND": 25, "DRUGBANK": 13, "MESH": 6 }, "object_id_prefixes": { "HP": 439, "NCIT": 22, "EFO": 8, "MESH": 5, "UMLS": 3 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object_category": [ "biolink:PhenotypicFeature" ], "count": 188, "primary_knowledge_sources": { "infores:ctd": 188 }, "qualifiers": {}, "attributes": { "id": 188, "category": 188, "publications": 188, "knowledge_level": 188, "agent_type": 188, "original_subject": 188, "original_object": 188 }, "subject_id_prefixes": { "CHEBI": 78, "PUBCHEM.COMPOUND": 64, "UNII": 46 }, "object_id_prefixes": { "HP": 166, "NCIT": 16, "UMLS": 3, "EFO": 2, "MESH": 1 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:BiologicalProcess" ], "count": 23, "primary_knowledge_sources": { "infores:ctd": 23 }, "qualifiers": {}, "attributes": { "id": 23, "category": 23, "publications": 23, "knowledge_level": 23, "agent_type": 23, "original_subject": 23, "original_object": 23 }, "subject_id_prefixes": { "CHEBI": 10, "PUBCHEM.COMPOUND": 8, "UNII": 5 }, "object_id_prefixes": { "GO": 23 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:Pathway" ], "count": 778, "primary_knowledge_sources": { "infores:ctd": 778 }, "qualifiers": {}, "attributes": { "id": 778, "category": 778, "knowledge_level": 778, "agent_type": 778, "p_value": 778, "adjusted_p_value": 778, "original_subject": 778, "original_object": 778 }, "subject_id_prefixes": { "CHEBI": 778 }, "object_id_prefixes": { "REACT": 586, "GO": 192 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:PhenotypicFeature" ], "count": 68, "primary_knowledge_sources": { "infores:ctd": 68 }, "qualifiers": {}, "attributes": { "id": 68, "category": 68, "publications": 68, "knowledge_level": 68, "agent_type": 68, "original_subject": 68, "original_object": 68 }, "subject_id_prefixes": { "MESH": 41, "CHEBI": 27 }, "object_id_prefixes": { "HP": 32, "MESH": 16, "UMLS": 9, "EFO": 8, "NCIT": 3 } }, { "subject_category": [ "biolink:Protein" ], "predicate": "biolink:correlated_with", "object_category": [ "biolink:PhenotypicFeature" ], "count": 355, "primary_knowledge_sources": { "infores:ctd": 355 }, "qualifiers": {}, "attributes": { "id": 355, "category": 355, "publications": 355, "knowledge_level": 355, "agent_type": 355, "original_subject": 355, "original_object": 355 }, "subject_id_prefixes": { "UMLS": 355 }, "object_id_prefixes": { "HP": 322, "NCIT": 25, "EFO": 3, "MESH": 3, "UMLS": 2 } }, { "subject_category": [ "biolink:Protein" ], "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object_category": [ "biolink:PhenotypicFeature" ], "count": 198, "primary_knowledge_sources": { "infores:ctd": 198 }, "qualifiers": {}, "attributes": { "id": 198, "category": 198, "publications": 198, "knowledge_level": 198, "agent_type": 198, "original_subject": 198, "original_object": 198 }, "subject_id_prefixes": { "UMLS": 198 }, "object_id_prefixes": { "HP": 161, "NCIT": 23, "UMLS": 7, "EFO": 4, "MESH": 3 } }, { "subject_category": [ "biolink:ComplexMolecularMixture" ], "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object_category": [ "biolink:Disease" ], "count": 363, "primary_knowledge_sources": { "infores:ctd": 363 }, "qualifiers": {}, "attributes": { "id": 363, "category": 363, "publications": 363, "knowledge_level": 363, "agent_type": 363, "original_subject": 363, "original_object": 363 }, "subject_id_prefixes": { "MESH": 363 }, "object_id_prefixes": { "MONDO": 296, "UMLS": 42, "EFO": 14, "MESH": 10, "OMIM": 1 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:Pathway" ], "count": 317, "primary_knowledge_sources": { "infores:ctd": 317 }, "qualifiers": { "species_context_qualifier": 317, "anatomical_context_qualifier": 317, "qualified_predicate": 267, "object_direction_qualifier": 267 }, "attributes": { "id": 317, "category": 317, "publications": 317, "knowledge_level": 317, "agent_type": 317, "original_subject": 317, "original_object": 317 }, "subject_id_prefixes": { "CHEBI": 312, "UNII": 4, "PUBCHEM.COMPOUND": 1 }, "object_id_prefixes": { "GO": 317 } }, { "subject_category": [ "biolink:ComplexMolecularMixture" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:Disease" ], "count": 227, "primary_knowledge_sources": { "infores:ctd": 227 }, "qualifiers": {}, "attributes": { "id": 227, "category": 227, "publications": 227, "knowledge_level": 227, "agent_type": 227, "original_subject": 227, "original_object": 227 }, "subject_id_prefixes": { "MESH": 227 }, "object_id_prefixes": { "MONDO": 202, "UMLS": 21, "DOID": 2, "EFO": 2 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:BiologicalProcess" ], "count": 114, "primary_knowledge_sources": { "infores:ctd": 114 }, "qualifiers": {}, "attributes": { "id": 114, "category": 114, "publications": 114, "knowledge_level": 114, "agent_type": 114, "original_subject": 114, "original_object": 114 }, "subject_id_prefixes": { "CHEBI": 114 }, "object_id_prefixes": { "GO": 114 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:BiologicalProcess" ], "count": 628, "primary_knowledge_sources": { "infores:ctd": 628 }, "qualifiers": { "species_context_qualifier": 628, "anatomical_context_qualifier": 628, "qualified_predicate": 460, "object_direction_qualifier": 460 }, "attributes": { "id": 628, "category": 628, "publications": 628, "knowledge_level": 628, "agent_type": 628, "original_subject": 628, "original_object": 628 }, "subject_id_prefixes": { "CHEBI": 617, "UNII": 7, "PUBCHEM.COMPOUND": 4 }, "object_id_prefixes": { "GO": 628 } }, { "subject_category": [ "biolink:ComplexMolecularMixture" ], "predicate": "biolink:affects", "object_category": [ "biolink:MolecularActivity" ], "count": 105, "primary_knowledge_sources": { "infores:ctd": 105 }, "qualifiers": { "species_context_qualifier": 105, "anatomical_context_qualifier": 105, "qualified_predicate": 103, "object_direction_qualifier": 103 }, "attributes": { "id": 105, "category": 105, "publications": 105, "knowledge_level": 105, "agent_type": 105, "original_subject": 105, "original_object": 105 }, "subject_id_prefixes": { "MESH": 105 }, "object_id_prefixes": { "GO": 105 } }, { "subject_category": [ "biolink:ComplexMolecularMixture" ], "predicate": "biolink:correlated_with", "object_category": [ "biolink:Disease" ], "count": 773, "primary_knowledge_sources": { "infores:ctd": 773 }, "qualifiers": {}, "attributes": { "id": 773, "category": 773, "publications": 773, "knowledge_level": 773, "agent_type": 773, "original_subject": 773, "original_object": 773 }, "subject_id_prefixes": { "MESH": 773 }, "object_id_prefixes": { "MONDO": 622, "UMLS": 109, "EFO": 29, "DOID": 6, "MESH": 6, "OMIM": 1 } }, { "subject_category": [ "biolink:ComplexMolecularMixture" ], "predicate": "biolink:correlated_with", "object_category": [ "biolink:PhenotypicFeature" ], "count": 209, "primary_knowledge_sources": { "infores:ctd": 209 }, "qualifiers": {}, "attributes": { "id": 209, "category": 209, "publications": 209, "knowledge_level": 209, "agent_type": 209, "original_subject": 209, "original_object": 209 }, "subject_id_prefixes": { "MESH": 209 }, "object_id_prefixes": { "HP": 142, "NCIT": 23, "MESH": 21, "EFO": 15, "UMLS": 8 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:correlated_with", "object_category": [ "biolink:Disease" ], "count": 175, "primary_knowledge_sources": { "infores:ctd": 175 }, "qualifiers": {}, "attributes": { "id": 175, "category": 175, "publications": 175, "knowledge_level": 175, "agent_type": 175, "original_subject": 175, "original_object": 175 }, "subject_id_prefixes": { "CHEBI": 167, "UNII": 4, "PUBCHEM.COMPOUND": 4 }, "object_id_prefixes": { "MONDO": 147, "UMLS": 19, "EFO": 5, "MESH": 4 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:BiologicalProcess" ], "count": 283, "primary_knowledge_sources": { "infores:ctd": 283 }, "qualifiers": {}, "attributes": { "id": 283, "category": 283, "publications": 283, "knowledge_level": 283, "agent_type": 283, "original_subject": 283, "original_object": 283 }, "subject_id_prefixes": { "CHEBI": 163, "MESH": 120 }, "object_id_prefixes": { "GO": 283 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object_category": [ "biolink:PhenotypicFeature" ], "count": 155, "primary_knowledge_sources": { "infores:ctd": 155 }, "qualifiers": {}, "attributes": { "id": 155, "category": 155, "publications": 155, "knowledge_level": 155, "agent_type": 155, "original_subject": 155, "original_object": 155 }, "subject_id_prefixes": { "CHEBI": 100, "PUBCHEM.COMPOUND": 23, "UNII": 20, "DRUGBANK": 6, "MESH": 4, "CHEMBL.COMPOUND": 2 }, "object_id_prefixes": { "HP": 131, "NCIT": 17, "EFO": 5, "MESH": 2 } }, { "subject_category": [ "biolink:Protein" ], "predicate": "biolink:affects", "object_category": [ "biolink:MolecularActivity" ], "count": 148, "primary_knowledge_sources": { "infores:ctd": 148 }, "qualifiers": { "species_context_qualifier": 148, "anatomical_context_qualifier": 148, "qualified_predicate": 143, "object_direction_qualifier": 143 }, "attributes": { "id": 148, "category": 148, "publications": 148, "knowledge_level": 148, "agent_type": 148, "original_subject": 148, "original_object": 148 }, "subject_id_prefixes": { "UMLS": 148 }, "object_id_prefixes": { "GO": 148 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:affects", "object_category": [ "biolink:CellularComponent" ], "count": 39, "primary_knowledge_sources": { "infores:ctd": 39 }, "qualifiers": { "species_context_qualifier": 39, "anatomical_context_qualifier": 39, "qualified_predicate": 36, "object_direction_qualifier": 36 }, "attributes": { "id": 39, "category": 39, "publications": 39, "knowledge_level": 39, "agent_type": 39, "original_subject": 39, "original_object": 39 }, "subject_id_prefixes": { "MESH": 32, "CHEBI": 5, "UNII": 2 }, "object_id_prefixes": { "GO": 39 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:Disease" ], "count": 150, "primary_knowledge_sources": { "infores:ctd": 150 }, "qualifiers": {}, "attributes": { "id": 150, "category": 150, "publications": 150, "knowledge_level": 150, "agent_type": 150, "original_subject": 150, "original_object": 150 }, "subject_id_prefixes": { "CHEBI": 149, "PUBCHEM.COMPOUND": 1 }, "object_id_prefixes": { "MONDO": 132, "UMLS": 17, "MESH": 1 } }, { "subject_category": [ "biolink:ChemicalMixture" ], "predicate": "biolink:associated_with", "object_category": [ "biolink:MolecularActivity" ], "count": 200, "primary_knowledge_sources": { "infores:ctd": 200 }, "qualifiers": {}, "attributes": { "id": 200, "category": 200, "knowledge_level": 200, "agent_type": 200, "p_value": 200, "adjusted_p_value": 200, "original_subject": 200, "original_object": 200 }, "subject_id_prefixes": { "CHEBI": 200 }, "object_id_prefixes": { "GO": 200 } }, { "subject_category": [ "biolink:ComplexMolecularMixture" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:BiologicalProcess" ], "count": 199, "primary_knowledge_sources": { "infores:ctd": 199 }, "qualifiers": {}, "attributes": { "id": 199, "category": 199, "publications": 199, "knowledge_level": 199, "agent_type": 199, "original_subject": 199, "original_object": 199 }, "subject_id_prefixes": { "MESH": 199 }, "object_id_prefixes": { "GO": 199 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:correlated_with", "object_category": [ "biolink:PhenotypicFeature" ], "count": 62, "primary_knowledge_sources": { "infores:ctd": 62 }, "qualifiers": {}, "attributes": { "id": 62, "category": 62, "publications": 62, "knowledge_level": 62, "agent_type": 62, "original_subject": 62, "original_object": 62 }, "subject_id_prefixes": { "CHEBI": 57, "UNII": 4, "PUBCHEM.COMPOUND": 1 }, "object_id_prefixes": { "HP": 57, "NCIT": 3, "EFO": 1, "MESH": 1 } }, { "subject_category": [ "biolink:Protein" ], "predicate": "biolink:affects", "object_category": [ "biolink:Pathway" ], "count": 33, "primary_knowledge_sources": { "infores:ctd": 33 }, "qualifiers": { "species_context_qualifier": 33, "anatomical_context_qualifier": 33, "qualified_predicate": 30, "object_direction_qualifier": 30 }, "attributes": { "id": 33, "category": 33, "publications": 33, "knowledge_level": 33, "agent_type": 33, "original_subject": 33, "original_object": 33 }, "subject_id_prefixes": { "UMLS": 33 }, "object_id_prefixes": { "GO": 33 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:PhenotypicFeature" ], "count": 31, "primary_knowledge_sources": { "infores:ctd": 31 }, "qualifiers": {}, "attributes": { "id": 31, "category": 31, "publications": 31, "knowledge_level": 31, "agent_type": 31, "original_subject": 31, "original_object": 31 }, "subject_id_prefixes": { "CHEBI": 31 }, "object_id_prefixes": { "MESH": 12, "HP": 11, "EFO": 6, "UMLS": 1, "NCIT": 1 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:Disease" ], "count": 68, "primary_knowledge_sources": { "infores:ctd": 68 }, "qualifiers": {}, "attributes": { "id": 68, "category": 68, "publications": 68, "knowledge_level": 68, "agent_type": 68, "original_subject": 68, "original_object": 68 }, "subject_id_prefixes": { "CHEBI": 35, "PUBCHEM.COMPOUND": 18, "UNII": 15 }, "object_id_prefixes": { "MONDO": 56, "UMLS": 8, "EFO": 4 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:CellularComponent" ], "count": 268, "primary_knowledge_sources": { "infores:ctd": 268 }, "qualifiers": { "species_context_qualifier": 268, "anatomical_context_qualifier": 268, "qualified_predicate": 224, "object_direction_qualifier": 224 }, "attributes": { "id": 268, "category": 268, "publications": 268, "knowledge_level": 268, "agent_type": 268, "original_subject": 268, "original_object": 268 }, "subject_id_prefixes": { "CHEBI": 254, "PUBCHEM.COMPOUND": 9, "UNII": 5 }, "object_id_prefixes": { "GO": 268 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:negatively_correlated_with", "object_category": [ "biolink:Disease" ], "count": 144, "primary_knowledge_sources": { "infores:ctd": 144 }, "qualifiers": {}, "attributes": { "id": 144, "category": 144, "publications": 144, "knowledge_level": 144, "agent_type": 144, "original_subject": 144, "original_object": 144 }, "subject_id_prefixes": { "CHEBI": 138, "PUBCHEM.COMPOUND": 4, "UNII": 2 }, "object_id_prefixes": { "MONDO": 136, "UMLS": 8 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:negatively_correlated_with", "object_category": [ "biolink:BiologicalProcess" ], "count": 62, "primary_knowledge_sources": { "infores:ctd": 62 }, "qualifiers": {}, "attributes": { "id": 62, "category": 62, "publications": 62, "knowledge_level": 62, "agent_type": 62, "original_subject": 62, "original_object": 62 }, "subject_id_prefixes": { "CHEBI": 61, "PUBCHEM.COMPOUND": 1 }, "object_id_prefixes": { "GO": 62 } }, { "subject_category": [ "biolink:Gene", "biolink:Protein" ], "predicate": "biolink:affects", "object_category": [ "biolink:BiologicalProcess" ], "count": 1, "primary_knowledge_sources": { "infores:ctd": 1 }, "qualifiers": { "species_context_qualifier": 1, "anatomical_context_qualifier": 1, "qualified_predicate": 1, "object_direction_qualifier": 1 }, "attributes": { "id": 1, "category": 1, "publications": 1, "knowledge_level": 1, "agent_type": 1, "original_subject": 1, "original_object": 1 }, "subject_id_prefixes": { "NCBIGene": 1 }, "object_id_prefixes": { "GO": 1 } }, { "subject_category": [ "biolink:ComplexMolecularMixture" ], "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object_category": [ "biolink:PhenotypicFeature" ], "count": 87, "primary_knowledge_sources": { "infores:ctd": 87 }, "qualifiers": {}, "attributes": { "id": 87, "category": 87, "publications": 87, "knowledge_level": 87, "agent_type": 87, "original_subject": 87, "original_object": 87 }, "subject_id_prefixes": { "MESH": 87 }, "object_id_prefixes": { "HP": 71, "NCIT": 8, "EFO": 5, "MESH": 3 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:affects", "object_category": [ "biolink:Pathway" ], "count": 79, "primary_knowledge_sources": { "infores:ctd": 79 }, "qualifiers": { "species_context_qualifier": 79, "anatomical_context_qualifier": 79, "qualified_predicate": 52, "object_direction_qualifier": 52 }, "attributes": { "id": 79, "category": 79, "publications": 79, "knowledge_level": 79, "agent_type": 79, "original_subject": 79, "original_object": 79 }, "subject_id_prefixes": { "MESH": 48, "CHEBI": 25, "UNII": 6 }, "object_id_prefixes": { "GO": 79 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:negatively_correlated_with", "object_category": [ "biolink:BiologicalProcess" ], "count": 20, "primary_knowledge_sources": { "infores:ctd": 20 }, "qualifiers": {}, "attributes": { "id": 20, "category": 20, "publications": 20, "knowledge_level": 20, "agent_type": 20, "original_subject": 20, "original_object": 20 }, "subject_id_prefixes": { "CHEBI": 12, "MESH": 8 }, "object_id_prefixes": { "GO": 20 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:negatively_correlated_with", "object_category": [ "biolink:Disease" ], "count": 30, "primary_knowledge_sources": { "infores:ctd": 30 }, "qualifiers": {}, "attributes": { "id": 30, "category": 30, "publications": 30, "knowledge_level": 30, "agent_type": 30, "original_subject": 30, "original_object": 30 }, "subject_id_prefixes": { "CHEBI": 30 }, "object_id_prefixes": { "MONDO": 27, "UMLS": 3 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:negatively_correlated_with", "object_category": [ "biolink:Disease" ], "count": 26, "primary_knowledge_sources": { "infores:ctd": 26 }, "qualifiers": {}, "attributes": { "id": 26, "category": 26, "publications": 26, "knowledge_level": 26, "agent_type": 26, "original_subject": 26, "original_object": 26 }, "subject_id_prefixes": { "CHEBI": 13, "MESH": 13 }, "object_id_prefixes": { "MONDO": 22, "UMLS": 3, "EFO": 1 } }, { "subject_category": [ "biolink:ComplexMolecularMixture" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:PhenotypicFeature" ], "count": 65, "primary_knowledge_sources": { "infores:ctd": 65 }, "qualifiers": {}, "attributes": { "id": 65, "category": 65, "publications": 65, "knowledge_level": 65, "agent_type": 65, "original_subject": 65, "original_object": 65 }, "subject_id_prefixes": { "MESH": 65 }, "object_id_prefixes": { "HP": 37, "MESH": 15, "UMLS": 6, "NCIT": 4, "EFO": 3 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:CellularComponent" ], "count": 109, "primary_knowledge_sources": { "infores:ctd": 109 }, "qualifiers": { "species_context_qualifier": 109, "anatomical_context_qualifier": 109, "qualified_predicate": 99, "object_direction_qualifier": 99 }, "attributes": { "id": 109, "category": 109, "publications": 109, "knowledge_level": 109, "agent_type": 109, "original_subject": 109, "original_object": 109 }, "subject_id_prefixes": { "CHEBI": 109 }, "object_id_prefixes": { "GO": 109 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:BiologicalProcess" ], "count": 13, "primary_knowledge_sources": { "infores:ctd": 13 }, "qualifiers": {}, "attributes": { "id": 13, "category": 13, "publications": 13, "knowledge_level": 13, "agent_type": 13, "original_subject": 13, "original_object": 13 }, "subject_id_prefixes": { "CHEBI": 13 }, "object_id_prefixes": { "GO": 13 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:negatively_correlated_with", "object_category": [ "biolink:PhenotypicFeature" ], "count": 38, "primary_knowledge_sources": { "infores:ctd": 38 }, "qualifiers": {}, "attributes": { "id": 38, "category": 38, "publications": 38, "knowledge_level": 38, "agent_type": 38, "original_subject": 38, "original_object": 38 }, "subject_id_prefixes": { "CHEBI": 36, "UNII": 1, "PUBCHEM.COMPOUND": 1 }, "object_id_prefixes": { "EFO": 24, "MESH": 7, "HP": 6, "UMLS": 1 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:affects", "object_category": [ "biolink:Pathway" ], "count": 29, "primary_knowledge_sources": { "infores:ctd": 29 }, "qualifiers": { "species_context_qualifier": 29, "anatomical_context_qualifier": 29, "qualified_predicate": 21, "object_direction_qualifier": 21 }, "attributes": { "id": 29, "category": 29, "publications": 29, "knowledge_level": 29, "agent_type": 29, "original_subject": 29, "original_object": 29 }, "subject_id_prefixes": { "CHEBI": 25, "PUBCHEM.COMPOUND": 3, "UNII": 1 }, "object_id_prefixes": { "GO": 29 } }, { "subject_category": [ "biolink:ComplexMolecularMixture" ], "predicate": "biolink:affects", "object_category": [ "biolink:CellularComponent" ], "count": 8, "primary_knowledge_sources": { "infores:ctd": 8 }, "qualifiers": { "species_context_qualifier": 8, "anatomical_context_qualifier": 8, "qualified_predicate": 6, "object_direction_qualifier": 6 }, "attributes": { "id": 8, "category": 8, "publications": 8, "knowledge_level": 8, "agent_type": 8, "original_subject": 8, "original_object": 8 }, "subject_id_prefixes": { "MESH": 8 }, "object_id_prefixes": { "GO": 8 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:PhenotypicFeature" ], "count": 235, "primary_knowledge_sources": { "infores:ctd": 235 }, "qualifiers": {}, "attributes": { "id": 235, "category": 235, "publications": 235, "knowledge_level": 235, "agent_type": 235, "original_subject": 235, "original_object": 235 }, "subject_id_prefixes": { "CHEBI": 230, "UNII": 3, "PUBCHEM.COMPOUND": 2 }, "object_id_prefixes": { "HP": 113, "MESH": 65, "EFO": 37, "UMLS": 11, "NCIT": 9 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object_category": [ "biolink:PhenotypicFeature" ], "count": 26, "primary_knowledge_sources": { "infores:ctd": 26 }, "qualifiers": {}, "attributes": { "id": 26, "category": 26, "publications": 26, "knowledge_level": 26, "agent_type": 26, "original_subject": 26, "original_object": 26 }, "subject_id_prefixes": { "CHEBI": 26 }, "object_id_prefixes": { "HP": 21, "NCIT": 3, "EFO": 2 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:negatively_correlated_with", "object_category": [ "biolink:PhenotypicFeature" ], "count": 18, "primary_knowledge_sources": { "infores:ctd": 18 }, "qualifiers": {}, "attributes": { "id": 18, "category": 18, "publications": 18, "knowledge_level": 18, "agent_type": 18, "original_subject": 18, "original_object": 18 }, "subject_id_prefixes": { "MESH": 11, "CHEBI": 7 }, "object_id_prefixes": { "EFO": 13, "HP": 3, "MESH": 2 } }, { "subject_category": [ "biolink:ComplexMolecularMixture" ], "predicate": "biolink:affects", "object_category": [ "biolink:Pathway" ], "count": 16, "primary_knowledge_sources": { "infores:ctd": 16 }, "qualifiers": { "species_context_qualifier": 16, "anatomical_context_qualifier": 16, "qualified_predicate": 8, "object_direction_qualifier": 8 }, "attributes": { "id": 16, "category": 16, "publications": 16, "knowledge_level": 16, "agent_type": 16, "original_subject": 16, "original_object": 16 }, "subject_id_prefixes": { "MESH": 16 }, "object_id_prefixes": { "GO": 16 } }, { "subject_category": [ "biolink:Protein" ], "predicate": "biolink:affects", "object_category": [ "biolink:CellularComponent" ], "count": 14, "primary_knowledge_sources": { "infores:ctd": 14 }, "qualifiers": { "species_context_qualifier": 14, "anatomical_context_qualifier": 14, "qualified_predicate": 10, "object_direction_qualifier": 10 }, "attributes": { "id": 14, "category": 14, "publications": 14, "knowledge_level": 14, "agent_type": 14, "original_subject": 14, "original_object": 14 }, "subject_id_prefixes": { "UMLS": 14 }, "object_id_prefixes": { "GO": 14 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:PhenotypicFeature" ], "count": 2, "primary_knowledge_sources": { "infores:ctd": 2 }, "qualifiers": {}, "attributes": { "id": 2, "category": 2, "publications": 2, "knowledge_level": 2, "agent_type": 2, "original_subject": 2, "original_object": 2 }, "subject_id_prefixes": { "CHEBI": 2 }, "object_id_prefixes": { "HP": 1, "EFO": 1 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:negatively_correlated_with", "object_category": [ "biolink:MolecularActivity" ], "count": 3, "primary_knowledge_sources": { "infores:ctd": 3 }, "qualifiers": {}, "attributes": { "id": 3, "category": 3, "publications": 3, "knowledge_level": 3, "agent_type": 3, "original_subject": 3, "original_object": 3 }, "subject_id_prefixes": { "CHEBI": 3 }, "object_id_prefixes": { "GO": 3 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:affects", "object_category": [ "biolink:Pathway" ], "count": 17, "primary_knowledge_sources": { "infores:ctd": 17 }, "qualifiers": { "species_context_qualifier": 17, "anatomical_context_qualifier": 17, "qualified_predicate": 13, "object_direction_qualifier": 13 }, "attributes": { "id": 17, "category": 17, "publications": 17, "knowledge_level": 17, "agent_type": 17, "original_subject": 17, "original_object": 17 }, "subject_id_prefixes": { "CHEBI": 17 }, "object_id_prefixes": { "GO": 17 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:BiologicalProcess" ], "count": 13, "primary_knowledge_sources": { "infores:ctd": 13 }, "qualifiers": {}, "attributes": { "id": 13, "category": 13, "publications": 13, "knowledge_level": 13, "agent_type": 13, "original_subject": 13, "original_object": 13 }, "subject_id_prefixes": { "CHEBI": 8, "DRUGBANK": 3, "UNII": 2 }, "object_id_prefixes": { "GO": 13 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:CellularComponent" ], "count": 2, "primary_knowledge_sources": { "infores:ctd": 2 }, "qualifiers": {}, "attributes": { "id": 2, "category": 2, "publications": 2, "knowledge_level": 2, "agent_type": 2, "original_subject": 2, "original_object": 2 }, "subject_id_prefixes": { "CHEBI": 1, "MESH": 1 }, "object_id_prefixes": { "GO": 2 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:negatively_correlated_with", "object_category": [ "biolink:Disease" ], "count": 4, "primary_knowledge_sources": { "infores:ctd": 4 }, "qualifiers": {}, "attributes": { "id": 4, "category": 4, "publications": 4, "knowledge_level": 4, "agent_type": 4, "original_subject": 4, "original_object": 4 }, "subject_id_prefixes": { "CHEBI": 4 }, "object_id_prefixes": { "MONDO": 3, "UMLS": 1 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:MolecularActivity" ], "count": 48, "primary_knowledge_sources": { "infores:ctd": 48 }, "qualifiers": { "species_context_qualifier": 48, "anatomical_context_qualifier": 48, "qualified_predicate": 45, "object_direction_qualifier": 45 }, "attributes": { "id": 48, "category": 48, "publications": 48, "knowledge_level": 48, "agent_type": 48, "original_subject": 48, "original_object": 48 }, "subject_id_prefixes": { "CHEBI": 48 }, "object_id_prefixes": { "GO": 48 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:treats_or_applied_or_studied_to_treat", "object_category": [ "biolink:Disease" ], "count": 53, "primary_knowledge_sources": { "infores:ctd": 53 }, "qualifiers": {}, "attributes": { "id": 53, "category": 53, "publications": 53, "knowledge_level": 53, "agent_type": 53, "original_subject": 53, "original_object": 53 }, "subject_id_prefixes": { "CHEBI": 53 }, "object_id_prefixes": { "MONDO": 43, "UMLS": 8, "EFO": 2 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:MolecularActivity" ], "count": 13, "primary_knowledge_sources": { "infores:ctd": 13 }, "qualifiers": {}, "attributes": { "id": 13, "category": 13, "publications": 13, "knowledge_level": 13, "agent_type": 13, "original_subject": 13, "original_object": 13 }, "subject_id_prefixes": { "CHEBI": 13 }, "object_id_prefixes": { "GO": 13 } }, { "subject_category": [ "biolink:ChemicalEntity" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:MolecularActivity" ], "count": 14, "primary_knowledge_sources": { "infores:ctd": 14 }, "qualifiers": {}, "attributes": { "id": 14, "category": 14, "publications": 14, "knowledge_level": 14, "agent_type": 14, "original_subject": 14, "original_object": 14 }, "subject_id_prefixes": { "CHEBI": 12, "MESH": 2 }, "object_id_prefixes": { "GO": 14 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:affects", "object_category": [ "biolink:CellularComponent" ], "count": 4, "primary_knowledge_sources": { "infores:ctd": 4 }, "qualifiers": { "species_context_qualifier": 4, "anatomical_context_qualifier": 4, "qualified_predicate": 4, "object_direction_qualifier": 4 }, "attributes": { "id": 4, "category": 4, "publications": 4, "knowledge_level": 4, "agent_type": 4, "original_subject": 4, "original_object": 4 }, "subject_id_prefixes": { "CHEBI": 4 }, "object_id_prefixes": { "GO": 4 } }, { "subject_category": [ "biolink:ComplexMolecularMixture" ], "predicate": "biolink:negatively_correlated_with", "object_category": [ "biolink:Disease" ], "count": 5, "primary_knowledge_sources": { "infores:ctd": 5 }, "qualifiers": {}, "attributes": { "id": 5, "category": 5, "publications": 5, "knowledge_level": 5, "agent_type": 5, "original_subject": 5, "original_object": 5 }, "subject_id_prefixes": { "MESH": 5 }, "object_id_prefixes": { "MONDO": 5 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:negatively_correlated_with", "object_category": [ "biolink:PhenotypicFeature" ], "count": 17, "primary_knowledge_sources": { "infores:ctd": 17 }, "qualifiers": {}, "attributes": { "id": 17, "category": 17, "publications": 17, "knowledge_level": 17, "agent_type": 17, "original_subject": 17, "original_object": 17 }, "subject_id_prefixes": { "CHEBI": 17 }, "object_id_prefixes": { "HP": 10, "MESH": 4, "EFO": 2, "NCIT": 1 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:affects", "object_category": [ "biolink:CellularComponent" ], "count": 26, "primary_knowledge_sources": { "infores:ctd": 26 }, "qualifiers": { "species_context_qualifier": 26, "anatomical_context_qualifier": 26, "qualified_predicate": 23, "object_direction_qualifier": 23 }, "attributes": { "id": 26, "category": 26, "publications": 26, "knowledge_level": 26, "agent_type": 26, "original_subject": 26, "original_object": 26 }, "subject_id_prefixes": { "CHEBI": 23, "PUBCHEM.COMPOUND": 2, "UNII": 1 }, "object_id_prefixes": { "GO": 26 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:Disease" ], "count": 10, "primary_knowledge_sources": { "infores:ctd": 10 }, "qualifiers": {}, "attributes": { "id": 10, "category": 10, "publications": 10, "knowledge_level": 10, "agent_type": 10, "original_subject": 10, "original_object": 10 }, "subject_id_prefixes": { "CHEBI": 10 }, "object_id_prefixes": { "MONDO": 10 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:CellularComponent" ], "count": 1, "primary_knowledge_sources": { "infores:ctd": 1 }, "qualifiers": {}, "attributes": { "id": 1, "category": 1, "publications": 1, "knowledge_level": 1, "agent_type": 1, "original_subject": 1, "original_object": 1 }, "subject_id_prefixes": { "CHEBI": 1 }, "object_id_prefixes": { "GO": 1 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:affects", "object_category": [ "biolink:CellularComponent" ], "count": 14, "primary_knowledge_sources": { "infores:ctd": 14 }, "qualifiers": { "species_context_qualifier": 14, "anatomical_context_qualifier": 14, "qualified_predicate": 13, "object_direction_qualifier": 13 }, "attributes": { "id": 14, "category": 14, "publications": 14, "knowledge_level": 14, "agent_type": 14, "original_subject": 14, "original_object": 14 }, "subject_id_prefixes": { "CHEBI": 14 }, "object_id_prefixes": { "GO": 14 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:Disease" ], "count": 20, "primary_knowledge_sources": { "infores:ctd": 20 }, "qualifiers": {}, "attributes": { "id": 20, "category": 20, "publications": 20, "knowledge_level": 20, "agent_type": 20, "original_subject": 20, "original_object": 20 }, "subject_id_prefixes": { "CHEBI": 17, "UNII": 3 }, "object_id_prefixes": { "MONDO": 16, "UMLS": 3, "EFO": 1 } }, { "subject_category": [ "biolink:ComplexMolecularMixture" ], "predicate": "biolink:negatively_correlated_with", "object_category": [ "biolink:BiologicalProcess" ], "count": 6, "primary_knowledge_sources": { "infores:ctd": 6 }, "qualifiers": {}, "attributes": { "id": 6, "category": 6, "publications": 6, "knowledge_level": 6, "agent_type": 6, "original_subject": 6, "original_object": 6 }, "subject_id_prefixes": { "MESH": 6 }, "object_id_prefixes": { "GO": 6 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:negatively_correlated_with", "object_category": [ "biolink:BiologicalProcess" ], "count": 5, "primary_knowledge_sources": { "infores:ctd": 5 }, "qualifiers": {}, "attributes": { "id": 5, "category": 5, "publications": 5, "knowledge_level": 5, "agent_type": 5, "original_subject": 5, "original_object": 5 }, "subject_id_prefixes": { "CHEBI": 5 }, "object_id_prefixes": { "GO": 5 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:PhenotypicFeature" ], "count": 12, "primary_knowledge_sources": { "infores:ctd": 12 }, "qualifiers": {}, "attributes": { "id": 12, "category": 12, "publications": 12, "knowledge_level": 12, "agent_type": 12, "original_subject": 12, "original_object": 12 }, "subject_id_prefixes": { "PUBCHEM.COMPOUND": 9, "CHEBI": 3 }, "object_id_prefixes": { "HP": 8, "NCIT": 2, "MESH": 2 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:Pathway" ], "count": 3, "primary_knowledge_sources": { "infores:ctd": 3 }, "qualifiers": {}, "attributes": { "id": 3, "category": 3, "publications": 3, "knowledge_level": 3, "agent_type": 3, "original_subject": 3, "original_object": 3 }, "subject_id_prefixes": { "CHEBI": 3 }, "object_id_prefixes": { "GO": 3 } }, { "subject_category": [ "biolink:ComplexMolecularMixture" ], "predicate": "biolink:negatively_correlated_with", "object_category": [ "biolink:PhenotypicFeature" ], "count": 7, "primary_knowledge_sources": { "infores:ctd": 7 }, "qualifiers": {}, "attributes": { "id": 7, "category": 7, "publications": 7, "knowledge_level": 7, "agent_type": 7, "original_subject": 7, "original_object": 7 }, "subject_id_prefixes": { "MESH": 7 }, "object_id_prefixes": { "EFO": 5, "MESH": 1, "HP": 1 } }, { "subject_category": [ "biolink:Protein" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:BiologicalProcess" ], "count": 1, "primary_knowledge_sources": { "infores:ctd": 1 }, "qualifiers": {}, "attributes": { "id": 1, "category": 1, "publications": 1, "knowledge_level": 1, "agent_type": 1, "original_subject": 1, "original_object": 1 }, "subject_id_prefixes": { "UMLS": 1 }, "object_id_prefixes": { "GO": 1 } }, { "subject_category": [ "biolink:SmallMolecule" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:CellularComponent" ], "count": 5, "primary_knowledge_sources": { "infores:ctd": 5 }, "qualifiers": {}, "attributes": { "id": 5, "category": 5, "publications": 5, "knowledge_level": 5, "agent_type": 5, "original_subject": 5, "original_object": 5 }, "subject_id_prefixes": { "CHEBI": 5 }, "object_id_prefixes": { "GO": 5 } }, { "subject_category": [ "biolink:ChemicalMixture" ], "predicate": "biolink:affects", "object_category": [ "biolink:BiologicalProcess" ], "count": 3, "primary_knowledge_sources": { "infores:ctd": 3 }, "qualifiers": { "species_context_qualifier": 3, "anatomical_context_qualifier": 3, "qualified_predicate": 3, "object_direction_qualifier": 3 }, "attributes": { "id": 3, "category": 3, "publications": 3, "knowledge_level": 3, "agent_type": 3, "original_subject": 3, "original_object": 3 }, "subject_id_prefixes": { "CHEBI": 3 }, "object_id_prefixes": { "GO": 3 } }, { "subject_category": [ "biolink:Protein" ], "predicate": "biolink:negatively_correlated_with", "object_category": [ "biolink:PhenotypicFeature" ], "count": 1, "primary_knowledge_sources": { "infores:ctd": 1 }, "qualifiers": {}, "attributes": { "id": 1, "category": 1, "publications": 1, "knowledge_level": 1, "agent_type": 1, "original_subject": 1, "original_object": 1 }, "subject_id_prefixes": { "UMLS": 1 }, "object_id_prefixes": { "HP": 1 } }, { "subject_category": [ "biolink:ComplexMolecularMixture" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:CellularComponent" ], "count": 1, "primary_knowledge_sources": { "infores:ctd": 1 }, "qualifiers": {}, "attributes": { "id": 1, "category": 1, "publications": 1, "knowledge_level": 1, "agent_type": 1, "original_subject": 1, "original_object": 1 }, "subject_id_prefixes": { "MESH": 1 }, "object_id_prefixes": { "GO": 1 } }, { "subject_category": [ "biolink:ChemicalMixture" ], "predicate": "biolink:affects", "object_category": [ "biolink:Gene", "biolink:Protein" ], "count": 4, "primary_knowledge_sources": { "infores:ctd": 4 }, "qualifiers": { "object_aspect_qualifier": 4, "object_direction_qualifier": 4, "qualified_predicate": 4, "species_context_qualifier": 4 }, "attributes": { "id": 4, "category": 4, "publications": 4, "knowledge_level": 4, "agent_type": 4, "original_subject": 4, "original_object": 4 }, "subject_id_prefixes": { "CHEBI": 4 }, "object_id_prefixes": { "NCBIGene": 4 } }, { "subject_category": [ "biolink:MolecularMixture" ], "predicate": "biolink:negatively_correlated_with", "object_category": [ "biolink:PhenotypicFeature" ], "count": 1, "primary_knowledge_sources": { "infores:ctd": 1 }, "qualifiers": {}, "attributes": { "id": 1, "category": 1, "publications": 1, "knowledge_level": 1, "agent_type": 1, "original_subject": 1, "original_object": 1 }, "subject_id_prefixes": { "CHEBI": 1 }, "object_id_prefixes": { "MESH": 1 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:negatively_correlated_with", "object_category": [ "biolink:MolecularActivity" ], "count": 1, "primary_knowledge_sources": { "infores:ctd": 1 }, "qualifiers": {}, "attributes": { "id": 1, "category": 1, "publications": 1, "knowledge_level": 1, "agent_type": 1, "original_subject": 1, "original_object": 1 }, "subject_id_prefixes": { "CHEBI": 1 }, "object_id_prefixes": { "GO": 1 } }, { "subject_category": [ "biolink:ComplexMolecularMixture" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:Pathway" ], "count": 1, "primary_knowledge_sources": { "infores:ctd": 1 }, "qualifiers": {}, "attributes": { "id": 1, "category": 1, "publications": 1, "knowledge_level": 1, "agent_type": 1, "original_subject": 1, "original_object": 1 }, "subject_id_prefixes": { "MESH": 1 }, "object_id_prefixes": { "GO": 1 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:PhenotypicFeature" ], "count": 2, "primary_knowledge_sources": { "infores:ctd": 2 }, "qualifiers": {}, "attributes": { "id": 2, "category": 2, "publications": 2, "knowledge_level": 2, "agent_type": 2, "original_subject": 2, "original_object": 2 }, "subject_id_prefixes": { "UNII": 1, "CHEBI": 1 }, "object_id_prefixes": { "HP": 1, "MESH": 1 } }, { "subject_category": [ "biolink:MolecularMixture", "biolink:SmallMolecule" ], "predicate": "biolink:negatively_correlated_with", "object_category": [ "biolink:Disease" ], "count": 1, "primary_knowledge_sources": { "infores:ctd": 1 }, "qualifiers": {}, "attributes": { "id": 1, "category": 1, "publications": 1, "knowledge_level": 1, "agent_type": 1, "original_subject": 1, "original_object": 1 }, "subject_id_prefixes": { "CHEBI": 1 }, "object_id_prefixes": { "MONDO": 1 } }, { "subject_category": [ "biolink:Protein" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:Disease" ], "count": 1, "primary_knowledge_sources": { "infores:ctd": 1 }, "qualifiers": {}, "attributes": { "id": 1, "category": 1, "publications": 1, "knowledge_level": 1, "agent_type": 1, "original_subject": 1, "original_object": 1 }, "subject_id_prefixes": { "UMLS": 1 }, "object_id_prefixes": { "MONDO": 1 } }, { "subject_category": [ "biolink:ComplexMolecularMixture" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:MolecularActivity" ], "count": 1, "primary_knowledge_sources": { "infores:ctd": 1 }, "qualifiers": {}, "attributes": { "id": 1, "category": 1, "publications": 1, "knowledge_level": 1, "agent_type": 1, "original_subject": 1, "original_object": 1 }, "subject_id_prefixes": { "MESH": 1 }, "object_id_prefixes": { "GO": 1 } }, { "subject_category": [ "biolink:Drug" ], "predicate": "biolink:negatively_correlated_with", "object_category": [ "biolink:Disease" ], "count": 2, "primary_knowledge_sources": { "infores:ctd": 2 }, "qualifiers": {}, "attributes": { "id": 2, "category": 2, "publications": 2, "knowledge_level": 2, "agent_type": 2, "original_subject": 2, "original_object": 2 }, "subject_id_prefixes": { "DRUGBANK": 1, "CHEBI": 1 }, "object_id_prefixes": { "MONDO": 2 } }, { "subject_category": [ "biolink:Drug", "biolink:SmallMolecule" ], "predicate": "biolink:positively_correlated_with", "object_category": [ "biolink:MolecularActivity" ], "count": 1, "primary_knowledge_sources": { "infores:ctd": 1 }, "qualifiers": {}, "attributes": { "id": 1, "category": 1, "publications": 1, "knowledge_level": 1, "agent_type": 1, "original_subject": 1, "original_object": 1 }, "subject_id_prefixes": { "CHEBI": 1 }, "object_id_prefixes": { "GO": 1 } } ], "edges_summary": { "total_count": 4191489, "predicates": { "biolink:associated_with": 2211460, "biolink:affects": 1869287, "biolink:correlated_with": 67463, "biolink:treats_or_applied_or_studied_to_treat": 38703, "biolink:positively_correlated_with": 4185, "biolink:negatively_correlated_with": 391 }, "primary_knowledge_sources": { "infores:ctd": 4191489 }, "predicates_by_knowledge_source": { "infores:ctd": { "biolink:associated_with": 2211460, "biolink:affects": 1869287, "biolink:correlated_with": 67463, "biolink:treats_or_applied_or_studied_to_treat": 38703, "biolink:positively_correlated_with": 4185, "biolink:negatively_correlated_with": 391 } }, "qualifiers": { "species_context_qualifier": 1869287, "qualified_predicate": 1844398, "object_aspect_qualifier": 1724153, "object_direction_qualifier": 1601279, "anatomical_context_qualifier": 116728 }, "attributes": { "id": 4191489, "category": 4191489, "knowledge_level": 4191489, "agent_type": 4191489, "original_subject": 4191489, "original_object": 4191489, "p_value": 2211460, "adjusted_p_value": 2211460, "publications": 1980029 } } }, "biolinkVersion": "4.3.7", "babelVersion": "2025sep1", "distribution": [], "hasPart": [], "isBasedOn": [ { "@type": "Dataset", "identifier": "ctd", "name": "CTD Resource Ingest Guide", "description": "CTD is a robust, publicly available database that aims to advance understanding about how environmental exposures affect human health. It provides knowledge, manually curated from the literature, about chemicals and their relationship to other biological entities: chemical to gene/protein interactions plus chemical to disease and gene to disease relationships. These data are integrated with functional and pathway data to aid in the development of hypotheses about the mechanisms underlying environmentally influenced diseases. It also generates novel inferences by further analyzing the knowledge they curate/create - based on statistically significant connections with intermediate concept (e.g. Chemical X associated with Disease Y based on shared associations with a common set of genes).", "license": { "terms_of_use_url": "https://ctdbase.org/about/legal.jsp", "terms_of_use_description": "Bespoke terms describing specific conditions for use of CTD data. No formal license." }, "url": [ "CTD Bulk Downloads - http://ctdbase.org/downloads/ (this page includes file sizes and simple data dictionaries for each download)", "CTD Catalog - https://ctdbase.org/reports/ (a simple list of files, reports the number of rows in each file)" ], "version": "April_2026" } ] }