{
  "source_type": "primary",
  "edges": [
    {
      "subject_category": "biolink:SmallMolecule",
      "object_category": "biolink:Gene",
      "predicate": "biolink:interacts_with",
      "subject_id": "CHEBI:228423",
      "object_id": "NCBIGene:5965"
    },
    {
      "subject_category": "biolink:SmallMolecule",
      "object_category": "biolink:Gene",
      "predicate": "biolink:directly_physically_interacts_with",
      "subject_id": "CHEBI:2666",
      "object_id": "NCBIGene:14"
    },
    {
      "subject_category": "biolink:SmallMolecule",
      "object_category": "biolink:Gene",
      "predicate": "biolink:affects",
      "subject_id": "CHEBI:8028",
      "object_id": "NCBIGene:3358",
      "qualifiers": [
        {
          "qualifier_type_id": "biolink:object_aspect_qualifier",
          "qualifier_value": "activity"
        },
        {
          "qualifier_type_id": "biolink:object_direction_qualifier",
          "qualifier_value": "decreased"
        },
        {
          "qualifier_type_id": "biolink:causal_mechanism_qualifier",
          "qualifier_value": "inhibition"
        },
        {
          "qualifier_type_id": "biolink:qualified_predicate",
          "qualifier_value": "biolink:causes"
        }
      ]
    },
    {
      "subject_category": "biolink:SmallMolecule",
      "object_category": "biolink:Protein",
      "predicate": "biolink:interacts_with",
      "subject_id": "CHEBI:228423",
      "object_id": "NCBIGene:5965"
    },
    {
      "subject_category": "biolink:SmallMolecule",
      "object_category": "biolink:Protein",
      "predicate": "biolink:directly_physically_interacts_with",
      "subject_id": "CHEBI:2666",
      "object_id": "NCBIGene:14"
    },
    {
      "subject_category": "biolink:SmallMolecule",
      "object_category": "biolink:Protein",
      "predicate": "biolink:affects",
      "subject_id": "CHEBI:8028",
      "object_id": "NCBIGene:3358",
      "qualifiers": [
        {
          "qualifier_type_id": "biolink:object_aspect_qualifier",
          "qualifier_value": "activity"
        },
        {
          "qualifier_type_id": "biolink:object_direction_qualifier",
          "qualifier_value": "decreased"
        },
        {
          "qualifier_type_id": "biolink:causal_mechanism_qualifier",
          "qualifier_value": "inhibition"
        },
        {
          "qualifier_type_id": "biolink:qualified_predicate",
          "qualifier_value": "biolink:causes"
        }
      ]
    },
    {
      "subject_category": "biolink:Gene",
      "object_category": "biolink:Protein",
      "predicate": "biolink:interacts_with",
      "subject_id": "NCBIGene:2113",
      "object_id": "NCBIGene:57410"
    },
    {
      "subject_category": "biolink:Gene",
      "object_category": "biolink:Gene",
      "predicate": "biolink:interacts_with",
      "subject_id": "NCBIGene:2113",
      "object_id": "NCBIGene:57410"
    },
    {
      "subject_category": "biolink:Protein",
      "object_category": "biolink:Gene",
      "predicate": "biolink:interacts_with",
      "subject_id": "UMLS:C4765363",
      "object_id": "NCBIGene:6403"
    },
    {
      "subject_category": "biolink:Protein",
      "object_category": "biolink:Gene",
      "predicate": "biolink:affects",
      "subject_id": "UMLS:C3886764",
      "object_id": "NCBIGene:2811",
      "qualifiers": [
        {
          "qualifier_type_id": "biolink:object_aspect_qualifier",
          "qualifier_value": "activity"
        },
        {
          "qualifier_type_id": "biolink:object_direction_qualifier",
          "qualifier_value": "decreased"
        },
        {
          "qualifier_type_id": "biolink:causal_mechanism_qualifier",
          "qualifier_value": "inhibition"
        },
        {
          "qualifier_type_id": "biolink:qualified_predicate",
          "qualifier_value": "biolink:causes"
        }
      ]
    },
    {
      "subject_category": "biolink:Protein",
      "object_category": "biolink:Gene",
      "predicate": "biolink:directly_physically_interacts_with",
      "subject_id": "UMLS:C2351370",
      "object_id": "NCBIGene:5289"
    },
    {
      "subject_category": "biolink:Protein",
      "object_category": "biolink:Protein",
      "predicate": "biolink:interacts_with",
      "subject_id": "UMLS:C4765363",
      "object_id": "NCBIGene:6403"
    },
    {
      "subject_category": "biolink:Protein",
      "object_category": "biolink:Protein",
      "predicate": "biolink:affects",
      "subject_id": "UMLS:C3886764",
      "object_id": "NCBIGene:2811",
      "qualifiers": [
        {
          "qualifier_type_id": "biolink:object_aspect_qualifier",
          "qualifier_value": "activity"
        },
        {
          "qualifier_type_id": "biolink:object_direction_qualifier",
          "qualifier_value": "decreased"
        },
        {
          "qualifier_type_id": "biolink:causal_mechanism_qualifier",
          "qualifier_value": "inhibition"
        },
        {
          "qualifier_type_id": "biolink:qualified_predicate",
          "qualifier_value": "biolink:causes"
        }
      ]
    },
    {
      "subject_category": "biolink:Protein",
      "object_category": "biolink:Protein",
      "predicate": "biolink:directly_physically_interacts_with",
      "subject_id": "UMLS:C2351370",
      "object_id": "NCBIGene:5289"
    },
    {
      "subject_category": "biolink:Drug",
      "object_category": "biolink:Gene",
      "predicate": "biolink:interacts_with",
      "subject_id": "UNII:DPT0O3T46P",
      "object_id": "NCBIGene:55193"
    },
    {
      "subject_category": "biolink:Drug",
      "object_category": "biolink:Gene",
      "predicate": "biolink:directly_physically_interacts_with",
      "subject_id": "CHEBI:2666",
      "object_id": "NCBIGene:14"
    },
    {
      "subject_category": "biolink:Drug",
      "object_category": "biolink:Gene",
      "predicate": "biolink:affects",
      "subject_id": "CHEBI:8028",
      "object_id": "NCBIGene:3358",
      "qualifiers": [
        {
          "qualifier_type_id": "biolink:object_aspect_qualifier",
          "qualifier_value": "activity"
        },
        {
          "qualifier_type_id": "biolink:object_direction_qualifier",
          "qualifier_value": "decreased"
        },
        {
          "qualifier_type_id": "biolink:causal_mechanism_qualifier",
          "qualifier_value": "inhibition"
        },
        {
          "qualifier_type_id": "biolink:qualified_predicate",
          "qualifier_value": "biolink:causes"
        }
      ]
    },
    {
      "subject_category": "biolink:Drug",
      "object_category": "biolink:Protein",
      "predicate": "biolink:interacts_with",
      "subject_id": "UNII:DPT0O3T46P",
      "object_id": "NCBIGene:55193"
    },
    {
      "subject_category": "biolink:Drug",
      "object_category": "biolink:Protein",
      "predicate": "biolink:directly_physically_interacts_with",
      "subject_id": "CHEBI:2666",
      "object_id": "NCBIGene:14"
    },
    {
      "subject_category": "biolink:Drug",
      "object_category": "biolink:Protein",
      "predicate": "biolink:affects",
      "subject_id": "CHEBI:8028",
      "object_id": "NCBIGene:3358",
      "qualifiers": [
        {
          "qualifier_type_id": "biolink:object_aspect_qualifier",
          "qualifier_value": "activity"
        },
        {
          "qualifier_type_id": "biolink:object_direction_qualifier",
          "qualifier_value": "decreased"
        },
        {
          "qualifier_type_id": "biolink:causal_mechanism_qualifier",
          "qualifier_value": "inhibition"
        },
        {
          "qualifier_type_id": "biolink:qualified_predicate",
          "qualifier_value": "biolink:causes"
        }
      ]
    },
    {
      "subject_category": "biolink:ChemicalEntity",
      "object_category": "biolink:Gene",
      "predicate": "biolink:interacts_with",
      "subject_id": "CHEMBL.COMPOUND:CHEMBL336095",
      "object_id": "NCBIGene:1544"
    },
    {
      "subject_category": "biolink:ChemicalEntity",
      "object_category": "biolink:Gene",
      "predicate": "biolink:affects",
      "subject_id": "DRUGBANK:DB16334",
      "object_id": "NCBIGene:3685",
      "qualifiers": [
        {
          "qualifier_type_id": "biolink:object_aspect_qualifier",
          "qualifier_value": "activity"
        },
        {
          "qualifier_type_id": "biolink:object_direction_qualifier",
          "qualifier_value": "decreased"
        },
        {
          "qualifier_type_id": "biolink:causal_mechanism_qualifier",
          "qualifier_value": "inhibition"
        },
        {
          "qualifier_type_id": "biolink:qualified_predicate",
          "qualifier_value": "biolink:causes"
        }
      ]
    },
    {
      "subject_category": "biolink:ChemicalEntity",
      "object_category": "biolink:Gene",
      "predicate": "biolink:directly_physically_interacts_with",
      "subject_id": "CHEMBL.COMPOUND:CHEMBL2109571",
      "object_id": "NCBIGene:50964"
    },
    {
      "subject_category": "biolink:ChemicalEntity",
      "object_category": "biolink:Protein",
      "predicate": "biolink:interacts_with",
      "subject_id": "CHEMBL.COMPOUND:CHEMBL336095",
      "object_id": "NCBIGene:1544"
    },
    {
      "subject_category": "biolink:ChemicalEntity",
      "object_category": "biolink:Protein",
      "predicate": "biolink:affects",
      "subject_id": "DRUGBANK:DB16334",
      "object_id": "NCBIGene:3685",
      "qualifiers": [
        {
          "qualifier_type_id": "biolink:object_aspect_qualifier",
          "qualifier_value": "activity"
        },
        {
          "qualifier_type_id": "biolink:object_direction_qualifier",
          "qualifier_value": "decreased"
        },
        {
          "qualifier_type_id": "biolink:causal_mechanism_qualifier",
          "qualifier_value": "inhibition"
        },
        {
          "qualifier_type_id": "biolink:qualified_predicate",
          "qualifier_value": "biolink:causes"
        }
      ]
    },
    {
      "subject_category": "biolink:ChemicalEntity",
      "object_category": "biolink:Protein",
      "predicate": "biolink:directly_physically_interacts_with",
      "subject_id": "CHEMBL.COMPOUND:CHEMBL2109571",
      "object_id": "NCBIGene:50964"
    },
    {
      "subject_category": "biolink:MolecularMixture",
      "object_category": "biolink:Gene",
      "predicate": "biolink:interacts_with",
      "subject_id": "CHEBI:31351",
      "object_id": "NCBIGene:4780"
    },
    {
      "subject_category": "biolink:MolecularMixture",
      "object_category": "biolink:Gene",
      "predicate": "biolink:directly_physically_interacts_with",
      "subject_id": "UNII:M6N3GK48A4",
      "object_id": "NCBIGene:6524"
    },
    {
      "subject_category": "biolink:MolecularMixture",
      "object_category": "biolink:Gene",
      "predicate": "biolink:affects",
      "subject_id": "CHEBI:134126",
      "object_id": "NCBIGene:415",
      "qualifiers": [
        {
          "qualifier_type_id": "biolink:object_aspect_qualifier",
          "qualifier_value": "activity"
        },
        {
          "qualifier_type_id": "biolink:object_direction_qualifier",
          "qualifier_value": "decreased"
        },
        {
          "qualifier_type_id": "biolink:causal_mechanism_qualifier",
          "qualifier_value": "molecular_channel_blockage"
        },
        {
          "qualifier_type_id": "biolink:qualified_predicate",
          "qualifier_value": "biolink:causes"
        }
      ]
    },
    {
      "subject_category": "biolink:MolecularMixture",
      "object_category": "biolink:Protein",
      "predicate": "biolink:interacts_with",
      "subject_id": "CHEBI:31351",
      "object_id": "NCBIGene:4780"
    },
    {
      "subject_category": "biolink:MolecularMixture",
      "object_category": "biolink:Protein",
      "predicate": "biolink:directly_physically_interacts_with",
      "subject_id": "UNII:M6N3GK48A4",
      "object_id": "NCBIGene:6524"
    },
    {
      "subject_category": "biolink:MolecularMixture",
      "object_category": "biolink:Protein",
      "predicate": "biolink:affects",
      "subject_id": "CHEBI:134126",
      "object_id": "NCBIGene:415",
      "qualifiers": [
        {
          "qualifier_type_id": "biolink:object_aspect_qualifier",
          "qualifier_value": "activity"
        },
        {
          "qualifier_type_id": "biolink:object_direction_qualifier",
          "qualifier_value": "decreased"
        },
        {
          "qualifier_type_id": "biolink:causal_mechanism_qualifier",
          "qualifier_value": "molecular_channel_blockage"
        },
        {
          "qualifier_type_id": "biolink:qualified_predicate",
          "qualifier_value": "biolink:causes"
        }
      ]
    }
  ]
}